腹腔镜袖状胃切除术（LSG）后，甘油三酯降低和血清脂蛋白脂肪酶水平升高与高密度脂蛋白胆固醇水平升高相关。

Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy.

机构信息

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.

Center for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.

出版信息

Obes Facts. 2021;14(6):633-640. doi: 10.1159/000519410. Epub 2021 Oct 11.

DOI:10.1159/000519410

PMID:34634786

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8739375/

Abstract

INTRODUCTION

Laparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG.

METHODS

We retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG.

RESULTS

A significant decrease was observed in the patients' BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG.

DISCUSSION/CONCLUSION: These results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG.

摘要

简介

腹腔镜袖状胃切除术（LSG）可显著增加肝素前血清中的高密度脂蛋白胆固醇（HDL-C）和脂蛋白脂肪酶（LPL）（肝素前 LPL 水平）。LPL 是血清甘油三酯（TG）和 HDL-C 产生的调节剂；这可能是 LSG 后 HDL-C 增加的机制。本研究旨在通过检查 LSG 后血清 HDL-C 水平和 LPL 的变化之间的关系，阐明 HDL-C 水平增加的机制。

方法

我们回顾性分析了 104 例肥胖患者，这些患者接受了 LSG 并随访了 12 个月。我们分析了 LSG 后血清 HDL-C 水平变化与各种临床参数之间的关系。

结果

LSG 后患者的 BMI 和血清 TG 水平明显下降。相反，HDL-C 水平和肝素前 LPL 水平明显升高。简单线性回归显示，HDL-C 水平的变化与总减重百分比、TG 水平的变化、腹部脂肪面积和肝素前 LPL 水平显著相关。此外，多元回归模型显示，TG 水平下降和肝素前 LPL 水平升高与 LSG 后 HDL-C 水平升高相关。

讨论/结论：这些结果表明，TG 水平下降和 LPL 增加是 LSG 后 HDL-C 水平升高的机制。