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Male hypogonadism caused by a homozygous missense mutation of the LHB gene.

作者信息

Chen Jie, Yi Wen-Ting, Cui Yuan-Qing, Wang Wen-Ting, Wang Xiong

机构信息

Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Laboratory Medicine, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, China.

出版信息

Korean J Intern Med. 2021 Nov;36(6):1527-1529. doi: 10.3904/kjim.2021.086. Epub 2021 Oct 12.

DOI:10.3904/kjim.2021.086
PMID:34634854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8588982/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3321/8588982/7c60ddccdcd4/kjim-2021-086f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3321/8588982/f12564501daf/kjim-2021-086f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3321/8588982/7c60ddccdcd4/kjim-2021-086f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3321/8588982/f12564501daf/kjim-2021-086f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3321/8588982/7c60ddccdcd4/kjim-2021-086f2.jpg

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本文引用的文献

1
Update on male reproductive endocrinology.男性生殖内分泌学的最新进展。
Transl Androl Urol. 2018 Jul;7(Suppl 3):S367-S372. doi: 10.21037/tau.2018.03.25.
2
Homozygous nonsense mutation Trp28X in the LHB gene causes male hypogonadism.LHB 基因中色氨酸 28 处同义突变导致男性低促性腺激素性性腺功能减退症。
J Assist Reprod Genet. 2018 May;35(5):913-919. doi: 10.1007/s10815-018-1133-5. Epub 2018 Feb 23.
3
Comment on "Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene".关于“促黄体生成素β亚基基因突变导致的低促性腺激素性性腺功能减退”的评论
Korean J Intern Med. 2017 May;32(3):566-567. doi: 10.3904/kjim.2017.088. Epub 2017 Apr 28.
4
Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene.由于促黄体生成素β亚基基因突变导致的低促性腺激素性性腺功能减退。
Korean J Intern Med. 2018 May;33(3):638-641. doi: 10.3904/kjim.2015.373. Epub 2017 Jan 16.
5
A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.黄体生成素突变揭示的人类糖蛋白激素运输的关键区域
J Endocrinol. 2016 Dec;231(3):197-207. doi: 10.1530/JOE-16-0384. Epub 2016 Sep 21.
6
Hypogonadism in a patient with two novel mutations of the luteinizing hormone β-subunit gene expressed in a compound heterozygous form.黄体生成素β亚单位基因突变的复合杂合形式导致患者出现低促性腺激素型性腺功能减退症。
J Clin Endocrinol Metab. 2012 Sep;97(9):3031-8. doi: 10.1210/jc.2012-1986. Epub 2012 Jun 21.
7
Normal spermatogenesis in a man with mutant luteinizing hormone.患有促黄体生成素突变的男性的正常精子发生。
N Engl J Med. 2009 Nov 5;361(19):1856-63. doi: 10.1056/NEJMoa0805792.
8
Luteinizing hormone beta mutation and hypogonadism in men and women.促黄体生成素β亚基突变与男性和女性性腺功能减退
N Engl J Med. 2007 Aug 30;357(9):897-904. doi: 10.1056/NEJMoa071999.
9
Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene.一名促黄体生成素β亚基基因突变患者的性腺功能减退。
N Engl J Med. 2004 Dec 16;351(25):2619-25. doi: 10.1056/NEJMoa040326.
10
Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.促黄体生成素β亚基单个氨基酸取代导致的性腺功能减退。
N Engl J Med. 1992 Jan 16;326(3):179-83. doi: 10.1056/NEJM199201163260306.