Rimmer E F, Turberville C, Horton M A
Exp Hematol. 1986 Oct;14(9):809-11.
The relationship of mast cells (MCs) to other blood leucocytes, and to basophils in particular, is unclear. The relative distribution and abundance of cell surface glycoproteins of normal and neoplastic blood cells has been established as providing a "fingerprint" allowing assignment to a particular hemopoietic cell lineage. We have examined the major labeled glycoproteins of mast cells, basophils, HL-60 cells (granulocytic), and U937 cells (monocytic), after cell surface tritiation by the periodate-borohydride technique. Mast cells have a characteristic glycoprotein profile, different from that of basophils and other leukocytes; a major feature is the lack of the gp105-115 molecular weight band common to all other white blood cells. The data suggest that the tissue mast cell is more distantly related to other hemopoietic cells than has been previously recognized.
肥大细胞（MCs）与其他血液白细胞，特别是与嗜碱性粒细胞的关系尚不清楚。正常血细胞和肿瘤血细胞的细胞表面糖蛋白的相对分布和丰度已被确定为提供一种“指纹”，可用于将其归属于特定的造血细胞谱系。我们使用高碘酸盐-硼氢化物技术对细胞表面进行氚标记后，检测了肥大细胞、嗜碱性粒细胞、HL-60细胞（粒细胞）和U937细胞（单核细胞）的主要标记糖蛋白。肥大细胞具有独特的糖蛋白谱，与嗜碱性粒细胞和其他白细胞不同；一个主要特征是缺乏所有其他白细胞共有的gp105-115分子量条带。数据表明，组织肥大细胞与其他造血细胞的关系比之前认为的更为疏远。
