Division of Pediatric Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, 535 E 70th St 5th Floor, New York, NY 10021, USA.
Department of Pediatrics, Division of Rheumatology, University of Alberta, 3-502 ECHA, 11405 87 Ave NW, Edmonton, AB T6G 1C9.
Rheum Dis Clin North Am. 2021 Nov;47(4):545-563. doi: 10.1016/j.rdc.2021.07.009. Epub 2021 Sep 2.
Juvenile idiopathic arthritis is a group of heterogeneous chronic inflammatory arthropathies occurring in childhood without a known cause. This article discusses the key clinical features of juvenile idiopathic arthritis and treatment updates for oligoarthritis, polyarthritis, enthesitis-related arthritis, psoriatic arthritis, and systemic arthritis. Paradigm changes in management include the earlier use of biologic agents and the introduction of biosimilars and targeted synthetic disease modifying agents like tofacitinib. This review summarizes recent developments while considering potential areas for improvement and study.
幼年特发性关节炎是一组异质性慢性炎症性关节病，发生于儿童期，病因不明。本文讨论了幼年特发性关节炎的主要临床特征，以及寡关节炎、多关节炎、附着点相关关节炎、银屑病关节炎和全身关节炎的治疗更新。治疗方法的范式转变包括更早地使用生物制剂，以及生物类似药和托法替尼等靶向合成疾病修正药物的引入。本综述总结了最新进展，同时考虑了潜在的改进和研究领域。
