WNT5B 在细胞信号通路中的作用。

WNT5B in cellular signaling pathways.

机构信息

Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, USA.

Department of Medicine, Division of Hematology and Oncology, University of Tennessee Health Science Center, Memphis, TN, USA; Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.

出版信息

Semin Cell Dev Biol. 2022 May;125:11-16. doi: 10.1016/j.semcdb.2021.09.019. Epub 2021 Oct 9.

DOI:10.1016/j.semcdb.2021.09.019

PMID:34635443

Abstract

The Wnt signaling ligand WNT5B is implicated in various developmental pathways, both in normal and pathological physiology. Most of the research on WNT5B has been associated with expression analysis and disease states, leaving the signaling pathways underexplored. Here, we review the current understandings of WNT5B's regulation of signal transduction, from receptors to downstream mediators and transcription factors. We also describe its roles in β-catenin-dependent and β-catenin-independent (Planar Cell Polarity and Wnt/Ca) Wnt signaling.

摘要

Wnt 信号配体 WNT5B 参与多种发育途径，包括正常生理和病理生理。对 WNT5B 的大部分研究都与表达分析和疾病状态有关，而对信号转导途径的研究则较少。本文综述了 WNT5B 对信号转导的调控作用，包括从受体到下游介质和转录因子。还描述了它在β-连环蛋白依赖性和β-连环蛋白非依赖性（平面细胞极性和 Wnt/Ca）Wnt 信号中的作用。