人类白细胞抗原与冠状动脉痉挛

Human leucocyte antigen and coronary artery spasm.

作者信息

Shimokawa H, Toyoda K, Matsumoto T, Sato H, Kikuchi Y, Nakamura M

出版信息

Int J Cardiol. 1986 Sep;12(3):362-5. doi: 10.1016/0167-5273(86)90273-1.

Abstract

To elucidate possible genetic links in the pathogenesis of coronary artery spasm, we investigated the frequencies of human leucocyte antigen in 37 patients with variant angina and 236 unrelated healthy controls. We found no significant differences in human leucocyte antigen frequencies between the patients and the controls. These results may suggest that genetic factors in linkage disequilibrium with human leucocyte antigen may not be involved in the pathogenesis of coronary artery spasm.

摘要

为了阐明冠状动脉痉挛发病机制中可能存在的遗传联系，我们调查了37例变异型心绞痛患者和236名无亲缘关系的健康对照者的人类白细胞抗原频率。我们发现患者与对照者之间的人类白细胞抗原频率无显著差异。这些结果可能表明，与人类白细胞抗原处于连锁不平衡状态的遗传因素可能不参与冠状动脉痉挛的发病机制。