Sandholm L, Tolo K
J Clin Periodontol. 1986 Aug;13(7):646-50. doi: 10.1111/j.1600-051x.1986.tb00859.x.
Serum antibody titers to Actinobacillus actinomycetemcomitans (A.a.) Y4, Bacteroides gingivalis, Capnocytophaga ochracea and Eubacterium saburreum were determined with an enzyme immunoassay in 12 patients with juvenile periodontitis (JP) at the beginning of treatment and 16 to 32 months later after clinically successful mechanical therapy without antibiotics. The values were compared to corresponding data obtained from 26 age- and sex-matched individuals with a healthy periodontium. 6 JP patients had significantly increased levels of IgG and IgA antibodies to A.a. and 2 patients had increased IgG and IgA antibodies to C.ochracea. About 75% of the JP patients had a level of IgG antibody to B.gingivalis and E.saburreum which was more than one SD lower than the mean of the healthy controls, and in the IgA class 80-100% had such decreased levels of antibodies to these bacteria. In the IgM class, the JP patients by and large had normal levels of antibodies to the 4 bacteria. After treatment, antibodies to A.a. had decreased in only 3 patients, but the levels were still significantly higher than in healthy controls. Minimal alterations were observed in the levels of antibodies to B.gingivalis, C.ochracea and E.saburreum after treatment.
采用酶免疫测定法，在12例青少年牙周炎（JP）患者治疗开始时以及在未使用抗生素的情况下临床机械治疗成功后16至32个月，测定了他们血清中抗伴放线放线杆菌（A.a.）Y4、牙龈拟杆菌、黄褐二氧化碳嗜纤维菌和纤细真杆菌的抗体滴度。将这些值与从26名年龄和性别匹配的牙周健康个体获得的相应数据进行比较。6例JP患者针对A.a.的IgG和IgA抗体水平显著升高，2例患者针对黄褐二氧化碳嗜纤维菌的IgG和IgA抗体升高。约75%的JP患者针对牙龈拟杆菌和纤细真杆菌的IgG抗体水平比健康对照组的平均值低一个标准差以上，在IgA类别中，80 - 100%针对这些细菌的抗体水平降低。在IgM类别中，JP患者针对这4种细菌的抗体水平总体上正常。治疗后，仅3例患者针对A.a.的抗体有所下降，但仍显著高于健康对照组。治疗后，针对牙龈拟杆菌、黄褐二氧化碳嗜纤维菌和纤细真杆菌的抗体水平变化极小。
