Department of Pharmacy, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87106, USA.
Department of Pharmacy, Duke University Medical Center, Durham, NC 27710, USA.
CNS Oncol. 2021 Dec 1;10(4):CNS78. doi: 10.2217/cns-2021-0006. Epub 2021 Oct 12.
Avascular necrosis (AVN) is a rare but serious adverse event associated with the use of corticosteroids for long durations or at high doses. This case report describes a 47-year-old female patient with low-grade astrocytoma who was initiated on low-dose dexamethasone for symptom management. The patient developed joint pain 1 year after steroid exposure, then was found to have AVN of the hip followed by multiple other joints. This case report highlights the extent to which AVN can occur in patients with brain tumors following a short course of low-dose corticosteroids. Careful evaluation of and monitoring for the development of AVN should occur frequently in patients with brain tumors given the frequent use of corticosteroids for symptom management in this population.
骨坏死（AVN）是一种罕见但严重的不良事件，与长期或高剂量使用皮质类固醇有关。本病例报告描述了一名 47 岁女性低度星形细胞瘤患者，她开始接受低剂量地塞米松进行症状管理。该患者在类固醇暴露 1 年后出现关节疼痛，随后发现髋部 AVN，随后多个其他关节也出现 AVN。本病例报告强调了脑肿瘤患者在短期低剂量皮质类固醇治疗后发生 AVN 的程度。鉴于皮质类固醇在该人群中常用于症状管理，因此应经常对脑肿瘤患者进行 AVN 的发生和发展进行仔细评估和监测。
