Servicio de Medicina Interna, Hospital General del Sur "Dr. Pedro Iturbe", Maracaibo, Venezuela.
Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo, Venezuela.
Curr Hypertens Rev. 2022;18(1):85-90. doi: 10.2174/1573402117666211005122757.
As a syndrome of physiological vulnerability and multifactorial progressive decline tightly related to age, frailty has been associated with several illnesses, and in particular cardiovascular disease.
To assess the factors associated with the frailty syndrome in older adults evaluated in the outpatient clinic of a tertiary hospital from Maracaibo city, Venezuela.
An observational, analytical, cross-sectional study was performed on subjects of both genders, over 60 years old that went to the Internal Medicine outpatient clinic of the Hospital General del Sur "Dr. Pedro Iturbe" from Maracaibo city, Venezuela. Sampling was performed via a non-probabilistic, intentional method. For each subject with frailty or pre-frailty, a control subject was selected in a 1:1 ratio according to gender; several risk factors were interrogated. The state of frailty was determined through the FRAIL scale.
Of the 201 assessed patients, 49.3% (n=99) were non-frail, 19.9% (n=40) were pre-frail and 30.8% (n=62) were frail. The population's overall age was 68.8±6.8 in non-frails, 69.1±7.7 in pre-frails, and 68.6±7.1 in frails. In the multivariate analysis, subjects with frailty and pre-frailty were most likely to be receiving polypharmacy (OR: 2.36, CI95%: 1.05-5.37; P=0.04) and have hypertension during the study (OR: 10.19, CI95%: 3.86-26.89; P<0.01).
The newly diagnosed hypertension and presence of polypharmacy were the factors most associated with frailty and pre-frailty in older adults evaluated in a tertiary hospital from Maracaibo city, Venezuela.
衰弱是一种与年龄密切相关的生理脆弱和多因素进行性下降的综合征，与多种疾病有关，特别是心血管疾病。
评估委内瑞拉马拉开波市一家三级医院门诊就诊的老年人衰弱综合征的相关因素。
这是一项观察性、分析性、横断面研究，研究对象为年龄在 60 岁以上的男性和女性，他们前往委内瑞拉马拉开波市的南方综合医院（Hospital General del Sur "Dr. Pedro Iturbe"）的内科门诊就诊。采用非概率、有目的的方法进行抽样。对于每一位衰弱或衰弱前期的患者，按照性别 1:1 的比例选择一位对照患者，并询问了一些危险因素。通过 FRAIL 量表来确定衰弱状态。
在评估的 201 名患者中，49.3%（n=99）为非衰弱，19.9%（n=40）为衰弱前期，30.8%（n=62）为衰弱。整个人群的平均年龄在非衰弱者中为 68.8±6.8 岁，在衰弱前期者中为 69.1±7.7 岁，在衰弱者中为 68.6±7.1 岁。在多变量分析中，患有衰弱和衰弱前期的患者更有可能正在接受多种药物治疗（OR：2.36，95%CI：1.05-5.37；P=0.04）和在研究期间患有高血压（OR：10.19，95%CI：3.86-26.89；P<0.01）。
在委内瑞拉马拉开波市的一家三级医院评估的老年人中，新诊断的高血压和存在多种药物治疗是与衰弱和衰弱前期最相关的因素。
