向大鼠黑质注射5,6-二羟基色胺后的行为及生化反应的初步研究。
A preliminary study on the behaviour and biochemical responses subsequent to the injection of 5,6-dihydroxytryptamine into the substantia nigra of the rat.
作者信息
Osborne N N, Neuhoff V, Sontag K H, Wolfarth S
出版信息
Experientia. 1978 Apr 15;34(4):495-6. doi: 10.1007/BF01935949.
PMID:346366
Abstract
Injection of 5,7-dihydroxytryptamine into the substantia nigra of rats produces an increase of dopamine in the ipsilateral striatum, and when these animals are injected with amphetamine they do not exhibit any rotation. The mode of action of this neurotoxin is compared with that of 6-hydroxydopamine.
摘要
向大鼠黑质注射5,7-二羟基色胺会使同侧纹状体中的多巴胺增加，并且当给这些动物注射苯丙胺时，它们不会出现任何旋转行为。将这种神经毒素的作用方式与6-羟基多巴胺的作用方式进行了比较。
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