Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Scand J Med Sci Sports. 2022 Feb;32(2):359-371. doi: 10.1111/sms.14079. Epub 2021 Oct 21.
Sporadic inclusion body myositis (sIBM) is an idiopathic inflammatory muscle disease associated with skeletal muscle inflammation and a parallel progressive decline in muscle strength and physical function. Eventually, most sIBM patients require use of wheelchair after about 10 years of diagnosis and assistance to perform activities of daily living. This study presents data from a randomized controlled intervention trial (NCT02317094) that examined the effect of 12 weeks low-load blood-flow restricted (BFR) resistance training on maximal muscle strength, power, rate of force development (RFD), thigh lean mass (TLM), and voluntary muscle activation (VA) in sIBM patients. A time-by-group interaction in knee extensor strength was observed in the stronger leg (p ≤ 0.033) but not the weaker leg. Within-group changes were observed with BFR training (BFR) manifested by increased knee extensor strength in the strongest leg (+13.7%, p = 0.049), whereas non-exercising patients (CON) showed reduced knee extensor strength (-7.7%, p = 0.018). Maximal leg extensor power obtained for the stronger leg remained unchanged following BFR training (+9.5%, p = 0.37) while decreasing in CON (-11.1%, p = 0.05). No changes in TLM were observed. VA declined post-training (p = 0.037) in both BFR (-6.3% points) and CON (-7.5% points). The present data indicate that BFR resistance training can attenuate the rate of decline in mechanical muscle function typically experienced by sIBM patients. The preservation of muscle mass and mechanical muscle function with BFR resistance training may be considered of high clinical importance in sIBM patients to countermeasure the disease-related decline in physical function.
散发性包涵体肌炎（sIBM）是一种特发性炎症性肌肉疾病，与骨骼肌炎症以及肌肉力量和身体功能的平行进行性下降有关。最终，大多数 sIBM 患者在诊断后约 10 年内需要使用轮椅，并需要协助才能进行日常生活活动。本研究提供了一项随机对照干预试验（NCT02317094）的数据，该试验检查了 12 周低负荷血流限制（BFR）抗阻训练对 sIBM 患者最大肌肉力量、功率、力量发展速率（RFD）、大腿瘦体重（TLM）和自愿肌肉激活（VA）的影响。在较强腿（p≤0.033）中观察到膝关节伸肌力量的时间-组间交互作用，但在较弱腿中没有观察到。在 BFR 训练（BFR）中观察到组内变化，最强腿的膝关节伸肌力量增加（+13.7%，p=0.049），而非运动患者（CON）的膝关节伸肌力量下降（-7.7%，p=0.018）。在 BFR 训练后，较强腿的最大腿部伸肌功率保持不变（+9.5%，p=0.37），而 CON 则下降（-11.1%，p=0.05）。TLM 没有变化。VA 在训练后下降（p=0.037），BFR（-6.3%点）和 CON（-7.5%点）均下降。本研究数据表明，BFR 抗阻训练可以减缓 sIBM 患者通常经历的机械肌肉功能下降速度。BFR 抗阻训练对肌肉质量和机械肌肉功能的保留可能被认为对 sIBM 患者具有重要的临床意义，可对抗与疾病相关的身体功能下降。
