Thames M D
Fed Proc. 1978 Apr;37(5):1209-13.
The role of cardiopulmonary receptors in the control of renal sympathetic nerve activity and of renin release is reviewed. The evidence indicates that cardiopulmonary receptors with vagal afferents exert a tonic inhibition on both renal nerve activity and on renin release. The magnitude of this inhibition appears directly related to changes in blood volume. Atrial as well as ventricular receptors can influence the secretion of renin. Cardiopulmonary receptors with vagal afferents may also reflexly modulate renal prostaglandin secretion. There is preliminary evidence to suggest that cardiopulmonary receptors with sympathetic afferents can influence renal nerve activity. The limitations of previous studies are outlined and a direction for future studies is suggested. It is concluded that alterations in cardiopulmonary vagal afferent input and the resulting changes in renal nerve activity and in renin release are appropriate for the maintenance of blood volume homeostasis.
本文综述了心肺感受器在控制肾交感神经活动和肾素释放中的作用。证据表明，具有迷走神经传入纤维的心肺感受器对肾神经活动和肾素释放均有紧张性抑制作用。这种抑制的程度似乎与血容量的变化直接相关。心房和心室感受器均可影响肾素分泌。具有迷走神经传入纤维的心肺感受器也可能通过反射调节肾前列腺素的分泌。有初步证据表明，具有交感神经传入纤维的心肺感受器可影响肾神经活动。文中概述了以往研究的局限性，并提出了未来研究的方向。得出的结论是，心肺迷走神经传入输入的改变以及由此导致的肾神经活动和肾素释放的变化，对于维持血容量稳态是合适的。
