Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
J Psychosom Res. 2021 Dec;151:110637. doi: 10.1016/j.jpsychores.2021.110637. Epub 2021 Oct 4.
The quantitative electroencephalography (qEEG) of patients with somatic symptom disorder (SSD) was not yet thoroughly studied. This study aimed to investigate qEEG of SSD patients compared with those of normal controls (NCs), and changes therein after treatment.
SSD patients currently without treatment and age- and sex-matched NCs were recruited. Spectral analysis of 64-channel EEG recording was performed and somatization, anxiety, and depression were evaluated via self-rating scales at baseline. After six months of treatment as usual, SSD patients were longitudinally followed up for assessments.
At baseline, the SSD group (n = 44) had higher alpha (p = 0.047) and lower beta 2 (p = 0.027) and gamma power (p = 0.001) compared with NCs (n = 29). After 6-month treatment, SSD patients showed improvement in symptoms, as well as increased beta 1 (p = 0.032), beta 2 (p = 0.012), and gamma power (p = 0.009) compared with baseline. A significant correlation was observed between the change in somatization score and temporal gamma power (r = -0.424, p = 0.031), and between the change in anxiety score and beta 2 power in the frontal (r = -0.420, p = 0.033) and central (r = -0.484, p = 0.012) regions.
EEG findings in this study may provide neurophysiological features of SSD. The alpha enhancement and reduced fast wave activity may reflect attentional dysfunction in patients with SSD. Decreased fast wave activity is reversible and may serve as a state marker of SSD.
躯体症状障碍（SSD）患者的定量脑电图（qEEG）尚未得到充分研究。本研究旨在比较 SSD 患者与正常对照者（NCs）的 qEEG，并观察治疗后的变化。
招募了目前未接受治疗且年龄和性别匹配的 SSD 患者和 NCs。对 64 通道脑电图记录进行频谱分析，并在基线时使用自评量表评估躯体化、焦虑和抑郁。在常规治疗 6 个月后，对 SSD 患者进行纵向随访评估。
基线时，SSD 组（n=44）的阿尔法频段（p=0.047）和贝塔 2 频段（p=0.027）及伽马频段（p=0.001）功率均高于 NCs（n=29）。治疗 6 个月后，SSD 患者的症状改善，β 1（p=0.032）、β 2（p=0.012）和γ 频段（p=0.009）功率增加。躯体化评分变化与颞部γ频段功率（r=-0.424，p=0.031）之间以及焦虑评分变化与额部（r=-0.420，p=0.033）和中央（r=-0.484，p=0.012）β 2 频段功率之间存在显著相关性。
本研究的脑电图结果可能为 SSD 提供神经生理学特征。阿尔法频段增强和快波活动减少可能反映 SSD 患者的注意力功能障碍。快波活动减少是可逆的，可能作为 SSD 的状态标志物。
