Robles-Cabrera Adriana, Torres-Arellano José M, Fossion Ruben, Lerma Claudia
Biomedical Sciences, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Department of Electromechanical Instrumentation, National Institute of Cardiology Ignacio Chávez, Mexico City 14080, Mexico.
J Clin Med. 2021 Sep 25;10(19):4386. doi: 10.3390/jcm10194386.
Heart rate variability (HRV) is a method used to evaluate the presence of cardiac autonomic neuropathy (CAN) because it is usually attributed to oscillations in cardiac autonomic nerve activity. Recent studies in other pathologies suggest that HRV indices are strongly related to mean heart rate, and this does not depend on autonomic activity only. This study aimed to evaluate the correlation between the mean heart rate and the HRV indices in women patients with well-controlled T2DM and a control group. HRV was evaluated in 19 T2DM women and 44 healthy women during basal supine position and two maneuvers: active standing and rhythmic breathing. Time-domain (SDNN, RMSSD, pNN20) and frequency-domain (LF, HF, LF/HF) indices were obtained. Our results show that meanNN, age, and the maneuvers are the main predictors of most HRV indices, while the diabetic condition was a predictor only for pNN20. Given the known reduced HRV in patients with T2DM, it is clinically important that much of the HRV indices are dependent on heart rate irrespective of the presence of T2DM. Moreover, the multiple regression analyses evidenced the multifactorial etiology of HRV.
心率变异性（HRV）是一种用于评估心脏自主神经病变（CAN）存在与否的方法，因为它通常归因于心脏自主神经活动的振荡。最近在其他病理状况下的研究表明，HRV指标与平均心率密切相关，且这不仅仅取决于自主神经活动。本研究旨在评估血糖控制良好的2型糖尿病女性患者与对照组中平均心率和HRV指标之间的相关性。在19名2型糖尿病女性和44名健康女性处于基础仰卧位以及进行两种动作（主动站立和有节奏呼吸）时评估HRV。获得了时域（SDNN、RMSSD、pNN20）和频域（LF、HF、LF/HF）指标。我们的结果表明，平均NN、年龄和动作是大多数HRV指标的主要预测因素，而糖尿病状况仅是pNN20的预测因素。鉴于已知2型糖尿病患者的HRV降低，临床上重要的是，无论是否存在2型糖尿病，许多HRV指标都依赖于心率。此外，多元回归分析证明了HRV的多因素病因。
