Rimfeld Kaili, Malanchini Margherita, Arathimos Ryan, Gidziela Agnieszka, Pain Oliver, McMillan Andrew, Ogden Rachel, Webster Louise, Packer Amy E, Shakeshaft Nicholas G, Schofield Kerry L, Pingault Jean-Baptiste, Allegrini Andrea G, Stringaris Argyris, von Stumm Sophie, Lewis Cathryn M, Plomin Robert
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Department of Psychology, Queen Mary University of London, London, UK.
medRxiv. 2021 Oct 7:2021.10.07.21264655. doi: 10.1101/2021.10.07.21264655.
The COVID-19 pandemic has impacted all our lives, not only through the infection itself, but also through the measures taken to control the virus’s spread (e.g., lockdown). Here we investigated how the COVID-19 pandemic and unprecedented lockdown affected the mental health of young adults in England and Wales. We compared the mental health symptoms of up to 4,000 twins in their mid-twenties in 2018 prior to the COVID-19 pandemic (T1) to those in a four-wave longitudinal data collection during the pandemic in April, July, and October 2020, and in March 2021 (T2-T5). The average changes in mental health were small-to-medium and mainly occurred from 2018 (T1) to March 2020 (T2, one month following the start of lockdown; average Cohen d=0.14). Despite the expectation of catastrophic effects on the pandemic on mental health of our young adults, we did not observe trends in worsening mental health during the pandemic (T3-T5). Young people with pre-existing mental health problems were adversely affected at the beginning of the pandemic, but their increased problems largely subsided as the pandemic persisted. Twin analyses indicated that the aetiology of individual differences did not change during the lockdown. The average heritability of mental health symptoms was 33% across 5 waves of assessment, and the average genetic correlation between T1 and T2-T5 was .95, indicating that genetic effects before the pandemic (T1) are substantially correlated with genetic effects up to a year later (T2-T5). We conclude that on average the mental health of young adults in England and Wales has been remarkably resilient to the effects of the pandemic and associated lockdown.
新冠疫情不仅通过感染本身,还通过为控制病毒传播而采取的措施(如封锁),影响了我们所有人的生活。在此,我们调查了新冠疫情及前所未有的封锁措施如何影响英格兰和威尔士年轻人的心理健康。我们将2018年新冠疫情爆发前(T1)25岁左右的多达4000对双胞胎的心理健康症状,与2020年4月、7月、10月以及2021年3月疫情期间四轮纵向数据收集时(T2-T5)的症状进行了比较。心理健康的平均变化为小到中等程度,主要发生在2018年(T1)到2020年3月(T2,封锁开始后一个月;平均科恩d值=0.14)。尽管预计疫情会对我们年轻人的心理健康产生灾难性影响,但我们并未观察到疫情期间(T3-T5)心理健康恶化的趋势。已有心理健康问题的年轻人在疫情开始时受到了不利影响,但随着疫情持续,他们增加的问题在很大程度上有所缓解。双胞胎分析表明,个体差异的病因在封锁期间没有变化。在五轮评估中,心理健康症状的平均遗传率为33%,T1与T2-T5之间的平均遗传相关性为0.95,这表明疫情前(T1)的遗传效应与一年后(T2-T5)的遗传效应高度相关。我们得出结论,平均而言,英格兰和威尔士年轻人的心理健康对疫情及相关封锁的影响具有显著的恢复力。