Rimfeld Kaili, Malanchini Margherita, Packer Amy E, Gidziela Agnieszka, Allegrini Andrea G, Ayorech Ziada, Smith-Woolley Emily, McMillan Andrew, Ogden Rachel, Dale Philip S, Eley Thalia C, Plomin Robert
Social, Genetic and Developmental Psychiatry Centre Institute of Psychiatry, Psychology and Neuroscience King's College London London UK.
Department of Psychology Queen Mary University of London London UK.
JCPP Adv. 2021 Dec 11;1(4):e12053. doi: 10.1002/jcv2.12053. eCollection 2021 Dec.
Here we report the results of the first systematic investigation of genetic and environmental influences on 57 psychological traits covering major issues in emerging adulthood such as aspirations, thoughts and attitudes, relationships and personality. We also investigate how these traits relate to physical and mental health, educational attainment and wellbeing.
MATERIALS & METHODS: We use a sample of nearly 5000 pairs of UK twins aged 21-25 from the Twins Early Development Study. We included 57 measures of traits selected to represent issues in emerging adulthood (EA) such as aspirations, thoughts and attitudes, life events, relationships, sexual and health behaviour and personality. We also included measures related to what are often considered to be the core functional outcomes even though here we refer to the data collected at the same time: adverse physical health, adverse mental health, wellbeing, and education.
All 57 traits showed significant genetic influence, with an average heritability of 34% (SNP heritability 10%). Most of the variance (59% on average) was explained by non-shared environmental influences. These diverse traits were associated with mental health (average correlation 0.20), wellbeing (0.16), physical health (0.12) and educational attainment (0.06). Shared genetic factors explained the majority of these correlations (50%). Together, these emerging adulthood traits explained on average 30% of variance in the outcomes (range = 8% to 69%), suggesting that these traits relate to the outcomes additively.
DISCUSSION & CONCLUSIONS: We conclude that even as the majority of individual differences in EA traits is explained by non-shared environmental factors, genetic influence on these traits is still substantial; the environmental uncertainties of emerging adulthood in the 21st century do not diminish the importance of genetics. As adolescents travel down long and winding roads to adulthood, their trip is substantially influenced by genetic proclivities that nudge them down different paths leading to different destinations.
在此,我们报告了对57种心理特质的遗传和环境影响的首次系统性调查结果,这些特质涵盖了成年初期的主要问题,如抱负、思想和态度、人际关系及个性。我们还研究了这些特质与身心健康、教育程度和幸福感之间的关系。
我们使用了来自双胞胎早期发展研究的近5000对年龄在21至25岁的英国双胞胎样本。我们纳入了57种特质测量指标,这些指标旨在代表成年初期(EA)的各种问题,如抱负、思想和态度、生活事件、人际关系、性与健康行为及个性。我们还纳入了与通常被认为是核心功能结果相关的测量指标,尽管在此我们提及的是同时收集的数据:不良身体健康状况、不良心理健康状况、幸福感和教育情况。
所有57种特质均显示出显著的遗传影响,平均遗传率为34%(单核苷酸多态性遗传率约为10%)。大部分变异(平均59%)由非共享环境影响所解释。这些多样的特质与心理健康(平均相关性为0.20)、幸福感(0.16)、身体健康(0.12)和教育程度(0.06)相关。共享遗传因素解释了这些相关性的大部分(约50%)。总体而言,这些成年初期特质平均解释了结果中30%的变异(范围为8%至69%),表明这些特质与结果呈累加关系。
我们得出结论,即使成年初期特质的大多数个体差异由非共享环境因素所解释,但遗传对这些特质的影响仍然很大;21世纪成年初期的环境不确定性并未削弱遗传学的重要性。当青少年在漫长而曲折的成年道路上前行时,他们的旅程受到遗传倾向的显著影响,这些倾向将他们推向不同的道路,通向不同的目的地。