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围手术期死亡和心搏骤停风险:来自全国经皮冠状动脉介入治疗登记研究(ORPKI)的 113456 例患者研究以评估围手术期预后。

Risk of perioperative death and sudden cardiac arrest: A study of 113 456 cases from the National Registry of Invasive Cardiology Procedures (ORPKI) for estimation of the perioperative prognosis.

机构信息

Collegium Medicum, Jan Kochanowski University, Kielce, Poland.

出版信息

Kardiol Pol. 2021;79(12):1328-1334. doi: 10.33963/KP.a2021.0133. Epub 2021 Oct 13.

DOI:10.33963/KP.a2021.0133
PMID:34643263
Abstract

BACKGROUND

Despite optimizing treatment of ST-segment elevation myocardial infarction (STEMI), a number of patients die during the invasive procedure or experience sudden cardiac arrest (SCA) that complicates further hospitalization.

AIMS

This study aimed to identify the most important risk factors leading to SCA and death in the cath lab among STEMI patients.

METHODS

We used data from the National Registry of Invasive Cardiology Procedures (ORPKI) collected between 2014 and 2019. The study population consisted of 113 465 patients. Descriptive statistics, univariate and multiple logistic regression analysis of factors affecting perioperative mortality (PM) and SCA in the cath lab were performed.

RESULTS

Death and SCA occurred in 1549 (1.4%) and 945 (0.8%) patients, respectively. Diabetes (odds ratio [OR], 1.76; P <0.0001), previous brain stroke (OR, 2.26; P <0.0001), prior myocardial infarction (OR, 1.81; P <0.0001), psoriasis (OR, 1.79; P = 0.04), and chronic renal failure (OR, 2.79; P <0.0001) were the strongest predictors of PM. The occurrence of SCA was dependent mainly on diabetes (OR, 1.37; P = 0.0001), previous brain stroke (OR, 2.23; P <0.0001), prior myocardial infarction (OR, 1.73; P <0.0001), psoriasis (OR, 2.03; P = 0.04), and chronic renal failure (OR, 2.79; P <0.0001). Of the pre-hospital factors, the Killip-Kimball class showed the strongest relationship with the two endpoints (OR 3.53; P <0.0001 and OR 2.65; P <0.0001, respectively).

CONCLUSIONS

Diabetes, previous brain stroke, myocardial infarction, psoriasis, chronic renal failure, and the Killip-Kimball class were the strongest predictors of PM and SCA in the cath lab among STEMI patients.

摘要

背景

尽管对 ST 段抬高型心肌梗死(STEMI)进行了优化治疗,但仍有许多患者在介入治疗过程中死亡,或发生心脏骤停(SCA),这使住院治疗变得更加复杂。

目的

本研究旨在确定 STEMI 患者在导管室发生 SCA 和死亡的最重要危险因素。

方法

我们使用了 2014 年至 2019 年期间国家介入心脏病学程序登记处(ORPKI)的数据。研究人群包括 113465 例患者。进行了描述性统计、单因素和多因素逻辑回归分析,以确定影响围手术期死亡率(PM)和导管室 SCA 的因素。

结果

死亡和 SCA 分别发生在 1549 例(1.4%)和 945 例(0.8%)患者中。糖尿病(比值比 [OR],1.76;P<0.0001)、既往脑卒(OR,2.26;P<0.0001)、既往心肌梗死(OR,1.81;P<0.0001)、银屑病(OR,1.79;P=0.04)和慢性肾衰竭(OR,2.79;P<0.0001)是 PM 的最强预测因素。SCA 的发生主要取决于糖尿病(OR,1.37;P=0.0001)、既往脑卒(OR,2.23;P<0.0001)、既往心肌梗死(OR,1.73;P<0.0001)、银屑病(OR,2.03;P=0.04)和慢性肾衰竭(OR,2.79;P<0.0001)。在院前因素中,Killip-Kimball 分级与两个终点的关系最强(OR 3.53;P<0.0001 和 OR 2.65;P<0.0001)。

结论

糖尿病、既往脑卒、心肌梗死、银屑病、慢性肾衰竭和 Killip-Kimball 分级是 STEMI 患者在导管室发生 PM 和 SCA 的最强预测因素。

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