Shenyang University of Chemical Technology, Shenyang, Liaoning, 110142, China.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Adv Healthc Mater. 2021 Dec;10(23):e2101542. doi: 10.1002/adhm.202101542. Epub 2021 Oct 19.
The penetration depth of near-infrared laser has greatly restricted the development of most photothermal agents. Recently, photothermal agents in the second near-infrared (NIR-II) window have drawn great attention as they can overcome above barrier. Herein, a novel "all in one" NIR-II responsive nanoplatform (nickel selenide @polydopamine nanocomposites, NiSe@PDA NCs) based on in situ coating the polydopamine (PDA) on the surface of biomineralized nickel selenide nanoparticles (NiSe NPs) for dual-model imaging-guided photothermal therapy is reported. Under the illumination of NIR-II laser (1064 nm), the photothermal conversion efficiency of NiSe@PDA NCs can reach 48.4%, which is higher than that of single NiSe NPs due to the enhanced molar extinction coefficient. In addition, because of the paramagnetic effect of NiSe NPs, the constructed NiSe@PDA NCs can be acted as T contrast agent for magnetic resonance imaging (MRI). Most importantly, the MRI contrast effect is enhanced with the coating of PDA layer due to the loose structure of PDA. Ultimately, both in vitro and in vivo experiments demonstrate that the developed NCs can achieve efficient MRI-guided photothermal therapy for treating malignant tumor. Therefore, the designed NiSe@PDA NCs with excellent features show great potential for clinical MRI-guided cancer therapy.
近红外激光的穿透深度极大地限制了大多数光热试剂的发展。最近，由于能够克服上述障碍，第二近红外（NIR-II）窗口中的光热试剂引起了极大的关注。在此，报道了一种基于原位在生物矿化硒化镍纳米颗粒（NiSe NPs）表面包覆聚多巴胺（PDA）的新型“一体化”NIR-II 响应纳米平台（硒化镍@聚多巴胺纳米复合材料，NiSe@PDA NCs），用于双模成像引导光热治疗。在 NIR-II 激光（1064nm）照射下，NiSe@PDA NCs 的光热转换效率可达 48.4%，高于单一的 NiSe NPs，这是由于增强了摩尔消光系数。此外，由于 NiSe NPs 的顺磁效应，构建的 NiSe@PDA NCs 可用作磁共振成像（MRI）的 T 造影剂。最重要的是，由于 PDA 层的松散结构，包覆 PDA 层后，MRI 对比效果得到增强。最终，体外和体内实验均表明，所开发的 NCs 可实现高效的 MRI 引导光热治疗以治疗恶性肿瘤。因此，具有优异特性的设计的 NiSe@PDA NCs 显示出用于临床 MRI 引导癌症治疗的巨大潜力。
