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[鼻出血——概述与当前情况]

[Epistaxis-overview and current aspects].

作者信息

Thangavelu Kruthika, Köhnlein Sabine, Eivazi Behfar, Gurschi Mariana, Stuck Boris A, Geisthoff Urban

机构信息

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Gießen und Marburg GmbH, Philipps-Universität Marburg, Baldingerstraße, 35043, Marburg, Deutschland.

MED-HNO, Schwerpunktpraxis für HNO-Heilkunde, Kopf-Hals-Chirurgie und Plastische Operationen am Alice Hospital Darmstadt, Darmstadt, Deutschland.

出版信息

HNO. 2021 Nov;69(11):931-942. doi: 10.1007/s00106-021-01110-4. Epub 2021 Oct 13.

DOI:10.1007/s00106-021-01110-4
PMID:34643746
Abstract

Nosebleeds (epistaxis) are usually minor. Medical intervention is only necessary in about 6% of cases. The source of bleeding is frequently located in the anterior region of the nose (Kiesselbach's plexus). The estimated lifetime prevalence of epistaxis is 60%. Diffuse epistaxis is often a manifestation of systemic disease. Epistaxis is the leading symptom of Rendu-Osler-Weber disease (hereditary hemorrhagic telangiectasia, HHT). If intervention is required, the first-choice of treatment is bidigital compression for several minutes. Common therapeutic measures include local hemostasis using electrocoagulation or chemical agents, e.g., silver nitrate. Resorbable anterior nasal tampons or tampons with a smooth surface are also frequently employed. In case of failed surgical closure of the sphenopalatine artery, angiographic embolization is the method of choice.

摘要

鼻出血通常并不严重。仅约6%的病例需要医学干预。出血部位常位于鼻腔前部(克氏静脉丛)。鼻出血的终生患病率估计为60%。弥漫性鼻出血常是全身性疾病的一种表现。鼻出血是遗传性出血性毛细血管扩张症(Rendu-Osler-Weber病,HHT)的主要症状。如果需要干预,首选治疗方法是双指压迫数分钟。常见的治疗措施包括使用电凝或化学制剂(如硝酸银)进行局部止血。也经常使用可吸收的前鼻孔填塞物或表面光滑的填塞物。如果蝶腭动脉手术结扎失败,血管造影栓塞是首选方法。

相似文献

1
[Epistaxis-overview and current aspects].[鼻出血——概述与当前情况]
HNO. 2021 Nov;69(11):931-942. doi: 10.1007/s00106-021-01110-4. Epub 2021 Oct 13.
2
Clinical Practice Guideline: Nosebleed (Epistaxis).临床实践指南:鼻出血(鼻衄)。
Otolaryngol Head Neck Surg. 2020 Jan;162(1_suppl):S1-S38. doi: 10.1177/0194599819890327.
3
[Embolization of branches of the external carotid artery in nosebleeds complicating Rendu-Osler-Weber disease].[鼻出血合并遗传性出血性毛细血管扩张症时颈外动脉分支的栓塞治疗]
Zh Vopr Neirokhir Im N N Burdenko. 1983 Jul-Aug(4):23-33.
4
[Intractable epistaxis in Osler-Rendu-Weber syndrome].[遗传性出血性毛细血管扩张症中的难治性鼻出血]
Rev Stomatol Chir Maxillofac. 2011 Nov;112(5):310-2. doi: 10.1016/j.stomax.2011.08.016. Epub 2011 Sep 21.
5
Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary.临床实践指南:鼻出血(鼻衄)执行摘要。
Otolaryngol Head Neck Surg. 2020 Jan;162(1):8-25. doi: 10.1177/0194599819889955.
6
Therapeutic embolization for control of epistaxis in a patient with hereditary hemorrhagic telangiectasia.遗传性出血性毛细血管扩张症患者鼻出血控制的治疗性栓塞术
Am J Otolaryngol. 1995 Mar-Apr;16(2):138-40. doi: 10.1016/0196-0709(95)90047-0.
7
Percutaneous embolization to control epistaxis in Rendu-Osler-Weber disease.经皮栓塞术治疗遗传性出血性毛细血管扩张症鼻出血
Arch Otolaryngol. 1976 Jan;102(1):58-60. doi: 10.1001/archotol.1976.00780060104017.
8
Epistaxis in patients with hereditary hemorrhagic telangiectasia treated with selective arterial embolization.遗传性出血性毛细血管扩张症患者选择性动脉栓塞治疗鼻出血
Acta Radiol. 2011 Oct 1;52(8):846-9. doi: 10.1258/ar.2011.110132. Epub 2011 Aug 4.
9
[Epistaxis in Rendu-Osler-Weber disease treated with selective embolization--case report].
Przegl Lek. 2012;69(7):317-9.
10
[Treatments of hereditary hemorrhagic telangiectasia of the nasal mucosa].[鼻腔黏膜遗传性出血性毛细血管扩张症的治疗]
Rev Laryngol Otol Rhinol (Bord). 2005;126(1):43-8.

本文引用的文献

1
Utilization of Prophylactic Antibiotics After Nasal Packing for Epistaxis.鼻填塞后预防性使用抗生素的情况。
J Emerg Med. 2021 Feb;60(2):144-149. doi: 10.1016/j.jemermed.2020.10.011. Epub 2020 Nov 7.
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Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia.遗传性出血性毛细血管扩张症诊断与管理的第二版国际指南。
Ann Intern Med. 2020 Dec 15;173(12):989-1001. doi: 10.7326/M20-1443. Epub 2020 Sep 8.
3
Trauma Can Induce Telangiectases in Hereditary Hemorrhagic Telangiectasia.创伤可诱发遗传性出血性毛细血管扩张症中的毛细血管扩张。
J Clin Med. 2020 May 17;9(5):1507. doi: 10.3390/jcm9051507.
4
Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary.临床实践指南:鼻出血(鼻衄)执行摘要。
Otolaryngol Head Neck Surg. 2020 Jan;162(1):8-25. doi: 10.1177/0194599819889955.
5
Prophylactic antibiotics for anterior nasal packing in emergency department: A systematic review and meta-analysis of clinically-significant infections.急诊科前鼻腔填塞预防性抗生素应用:临床显著感染的系统评价和荟萃分析。
Am J Emerg Med. 2020 May;38(5):983-989. doi: 10.1016/j.ajem.2019.11.037. Epub 2019 Nov 30.
6
Evaluating Effectiveness of Nasal Compression With Tranexamic Acid Compared With Simple Nasal Compression and Merocel Packing: A Randomized Controlled Trial.评价鼻腔压迫联合氨甲环酸与单纯鼻腔压迫和 Merocel 填塞治疗鼻出血的效果:一项随机对照试验。
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Nasal self-packing for epistaxis in Hereditary Hemorrhagic Telangiectasia increases quality of life.遗传性出血性毛细血管扩张症患者鼻出血的鼻腔自填塞可提高生活质量。
Rhinology. 2019 Jun 1;57(3):231-239. doi: 10.4193/Rhin18.141.
8
Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia.遗传性出血性毛细血管扩张症患者使用沙利度胺和贝伐珠单抗的安全性。
Orphanet J Rare Dis. 2019 Feb 4;14(1):28. doi: 10.1186/s13023-018-0982-4.
9
Prophylactic systemic antibiotics for anterior epistaxis treated with nasal packing in the ED.急诊经鼻腔填塞治疗前鼻出血的预防性全身抗生素治疗。
Am J Emerg Med. 2019 Apr;37(4):726-729. doi: 10.1016/j.ajem.2018.12.056. Epub 2018 Dec 29.
10
The role of oral anticoagulants in epistaxis.口服抗凝剂在鼻出血中的作用。
Eur Arch Otorhinolaryngol. 2018 Aug;275(8):2035-2043. doi: 10.1007/s00405-018-5043-z. Epub 2018 Jun 23.