Department of Paediatrics, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Eur J Pediatr. 2022 Mar;181(3):1263-1267. doi: 10.1007/s00431-021-04272-z. Epub 2021 Oct 13.
Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.
使用 2015 年在 MRC 冈比亚进行的匹配病例对照设计，我们测量了尽管与同一成人结核病例有相同的睡眠接近但结核菌素皮肤试验状态不一致的无症状儿童对的维生素 D 水平。组的中位数年龄（感染组为 10.0 岁，未感染组为 8.8 岁）无显著差异（p=0.13）。与 24 名匹配的高度结核暴露感染儿童相比，24 名高度结核暴露未感染儿童的平均维生素 D 水平高 2.05ng/mL（95%CI-0.288 至 4.38;p=0.08）。研究结果值得在更大的研究中进一步调查，以了解其意义和重要性。结论：与结核感染儿童相比，结核未感染儿童的维生素 D 水平更高，尽管他们都受到了高水平的结核病例暴露。
