Sica D A, Polk R E, Kerkering T M, Patterson P, Baggett J
Eur J Clin Pharmacol. 1986;30(6):713-7. doi: 10.1007/BF00608221.
The kinetics of the aminothiazolyliminomethoxy cephalosporin, cefmenoxime, were determined after a 30 min intravenous infusion of 15 mg/kg body weight in 6 adult subjects undergoing continuous ambulatory peritoneal dialysis. Concentrations of cefmenoxime in serum, urine and dialysate were determined by high-pressure liquid chromatography. The mean peak serum concentration was 92.8 +/- 11.6 micrograms/ml and the harmonic mean for the elimination half-life was 5.46 h. The volume of distribution at steady-state was 14.60 +/- 3.01 l/kg. Total body clearance of the drug was 31 +/- 7.7 ml/min with 8 +/- 5% and 5.75 +/- 2.72% of the administered dose being eliminated by renal and peritoneal clearance, respectively. Peritoneal clearance for all exchanges (n = 24) was 1.93 +/- 68 ml/min. These data suggest that peritoneal losses of this drug are minimal and doses conventionally employed in advanced renal failure can be utilized in the management of systemic infections.
在6名接受持续性非卧床腹膜透析的成年受试者中，静脉输注15mg/kg体重的氨噻唑基亚氨基甲氧基头孢菌素头孢甲肟30分钟后，测定其药代动力学。采用高压液相色谱法测定血清、尿液和透析液中头孢甲肟的浓度。血清平均峰浓度为92.8±11.6μg/ml，消除半衰期的调和平均值为5.46小时。稳态分布容积为14.60±3.01l/kg。该药的总体清除率为31±7.7ml/min，给药剂量分别有8±5%和5.75±2.72%经肾脏清除和腹膜清除。所有交换（n=24）的腹膜清除率为1.93±68ml/min。这些数据表明，该药的腹膜清除量极少，晚期肾衰竭时常规使用的剂量可用于全身性感染的治疗。
