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Rebuttal to: In Vivo Studies Should Take Priority When Defining Mechanisms of Intestinal Crypt Morphogenesis.对《在定义肠道隐窝形态发生机制时体内研究应优先考虑》的反驳
Cell Mol Gastroenterol Hepatol. 2022;13(1):5. doi: 10.1016/j.jcmgh.2021.09.010. Epub 2021 Oct 10.
2
In Vivo Studies Should Take Priority When Defining Mechanisms of Intestinal Crypt Morphogenesis.在定义肠道隐窝形态发生机制时，体内研究应优先进行。
Cell Mol Gastroenterol Hepatol. 2022;13(1):1-3. doi: 10.1016/j.jcmgh.2021.06.028. Epub 2021 Sep 22.
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Characterization of rat epimorphin/syntaxin 2 expression suggests a role in crypt-villus morphogenesis.大鼠表皮形态发生素/ syntaxin 2表达的特征表明其在隐窝-绒毛形态发生中起作用。
Am J Physiol. 1998 Jul;275(1):G114-24. doi: 10.1152/ajpgi.1998.275.1.G114.
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Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling.在利伯库恩小肠隐窝形态发生过程中，多能干细胞的选择受到Lef-1/β-连环蛋白信号通路刺激的干扰。
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Isolated crypts form spheres prior to full intestinal differentiation when grown as xenografts: an in vivo model for the study of intestinal differentiation and crypt neogenesis, and for the abnormal crypt architecture of juvenile polyposis coli.当作为异种移植生长时，分离的隐窝在完全肠分化之前形成球体：一种用于研究肠分化和隐窝新生以及幼年性息肉病综合征异常隐窝结构的体内模型。
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Intestinal development and differentiation.肠发育和分化。
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Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection.适应性小肠切除术后抑制刺猬信号通路后细胞凋亡增加和上皮迁移加速。
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Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.白细胞介素-11可预防联合化疗和放疗小鼠的细胞凋亡，并加速小肠黏膜的恢复。
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引用本文的文献

1
Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity.C57BL/6 小鼠肠类器官形态改变作为预测化学物诱导毒性的工具。
Arch Toxicol. 2023 Apr;97(4):1133-1146. doi: 10.1007/s00204-023-03451-1. Epub 2023 Feb 20.

Rebuttal to: In Vivo Studies Should Take Priority When Defining Mechanisms of Intestinal Crypt Morphogenesis.

作者信息

Sugimoto Shinya, Sato Toshiro

机构信息

Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.

Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.

出版信息

Cell Mol Gastroenterol Hepatol. 2022;13(1):5. doi: 10.1016/j.jcmgh.2021.09.010. Epub 2021 Oct 10.

DOI:10.1016/j.jcmgh.2021.09.010
PMID:34644540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8600056/
Abstract
摘要