局部外用米诺地尔对墨西哥无毛犬新生无毛后代毛囊生长的影响。

The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of Mexican hairless dogs.

作者信息

Kimura Tohru, Doi Kunio

机构信息

Research Center, Nihon Nosan Kogyo Co. Ltd, Takura 5246, Tsukuba, Ibaraki 300-26, Japan.

Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo, Yayoi 1-1-1, Bunkyo, Tokyo 113, Japan.

出版信息

Vet Dermatol. 1997 Jun;8(2):107-113. doi: 10.1046/j.1365-3164.1997.d01-7.x.

DOI:10.1046/j.1365-3164.1997.d01-7.x

PMID:34645063

Abstract

The effect of daily topical minoxidil treatment on hair growth was investigated in eight neonatal hairless pups. After 21 days of minoxidil treatment, hair growth occurred in the minoxidil-treated areas of each neonatal hairless pup. The numbers of hairs in the treated areas increased as compared with that in the areas treated with vehicle only. Histological findings revealed that the skin treated with minoxidil contained many hair follicles derived from epidermal ingrowths (hair germs) projecting into the dermis. These hair follicles showed various stages of neofolliculogenesis. After 31 days of treatment, terminal hair growth was observed. In the minoxidil-untreated areas, epidermal ingrowths remained undifferentiated. These results revealed that hairless dogs developed hair growth reactions following minoxidil-treatment when such treatment is applied in the early neonatal period. Neonatal hairless pups are a useful model for evaluating the effectiveness of hair growth stimulators.

摘要

在八只新生无毛幼崽中研究了每日局部使用米诺地尔治疗对毛发生长的影响。米诺地尔治疗21天后，每只新生无毛幼崽经米诺地尔治疗的部位出现了毛发生长。与仅用赋形剂治疗的部位相比，治疗部位的毛发数量增加。组织学结果显示，用米诺地尔治疗的皮肤含有许多源自向真皮内生长的表皮（毛胚）的毛囊。这些毛囊呈现出不同阶段的新毛囊形成。治疗31天后，观察到终毛生长。在未用米诺地尔治疗的部位，表皮向内生长仍未分化。这些结果表明，在新生儿早期应用米诺地尔治疗时，无毛犬会出现毛发生长反应。新生无毛幼崽是评估毛发生长刺激剂有效性的有用模型。