Munkhsukh Munkh-Undral, Namjil Darisuren, Byambajav Puntsagdulam, Angarag Enkh-Amgalan, Junai Suvd, Dagvajantsan Byambasuren, Byambasukh Oyuntugs
Department of Endocrinology, School of Medicine, Mongolian National University of Medical Sciences, 13270 Ulaanbaatar, Mongolia.
Department of Neurology, School of Medicine, Mongolian National University of Medical Sciences, 13270 Ulaanbaatar, Mongolia.
J Integr Neurosci. 2021 Sep 30;20(3):659-666. doi: 10.31083/j.jin2003070.
People with diabetes have a higher risk of cognitive impairment than people without diabetes, and recently it is being considered a complication of diabetes mellitus (DM). Because of drastic lifestyle changes in the Mongolian population, diabetes prevalence is increasing rapidly. The rapid increase of diabetes prevalence and its poor control in Mongolia suggest that there might be significant cognitive impairment in the diabetes population. In this case-control study, we compared the Mini-Mental State Examination score to the risk of cognitive impairment, indicating vascular dementia in people with and without diabetes. Upon obtaining their informed consent, each subject was tested with Mini-Mental State Examination. We involved age and gender-matched diabetic (n = 131) and non-diabetic (n = 131) subjects. The mean age was 61.3 ± 8.5 and 61.0 ± 8.7 in people with and without diabetes, respectively, and 35.9% of the participants were male. According to study groups, the Mini-Mental State Examination scores were significantly different: 26.1 ± 3.7 and 27.5 ± 2.6 for people with and without diabetes, respectively. In logistic regression analysis, age was significantly associated with Mini-Mental State Examination score (Beta coefficient = 1.22; 1.11-1.35, < 0.001) in people without diabetes after adjustments for potential confounders. However, age was not significantly associated with MMSE scores in people with diabetes mellitus. Thus, diabetes duration and poor control may contribute to developing cognitive impairment in people with diabetes. In conclusion, there might be a high prevalence of vascular dementia in people with type 2 diabetes mellitus. However, since Mini-Mental State Examination is sensitive to dementia and not specific to vascular dementia, further studies involving neuroimaging and neurological examination are needed to fully elucidate the link between type 2 diabetes and vascular dementia in dementia in a Mongolian population.
糖尿病患者比非糖尿病患者患认知障碍的风险更高，最近它被认为是糖尿病（DM）的一种并发症。由于蒙古人群生活方式的急剧变化，糖尿病患病率正在迅速上升。蒙古糖尿病患病率的快速上升及其控制不佳表明，糖尿病患者中可能存在显著的认知障碍。在这项病例对照研究中，我们将简易精神状态检查表得分与认知障碍风险进行了比较，该风险表明糖尿病患者和非糖尿病患者中存在血管性痴呆。在获得他们的知情同意后，每个受试者都接受了简易精神状态检查表测试。我们纳入了年龄和性别匹配的糖尿病患者（n = 131）和非糖尿病患者（n = 131）。糖尿病患者和非糖尿病患者的平均年龄分别为61.3±8.5岁和61.0±8.7岁，35.9%的参与者为男性。根据研究组，简易精神状态检查表得分存在显著差异：糖尿病患者和非糖尿病患者分别为26.1±3.7和27.5±2.6。在逻辑回归分析中，在对潜在混杂因素进行调整后，年龄与非糖尿病患者的简易精神状态检查表得分显著相关（β系数 = 1.22；1.11 - 1.35，<0.001）。然而，年龄与糖尿病患者的MMSE得分没有显著相关性。因此，糖尿病病程和控制不佳可能导致糖尿病患者出现认知障碍。总之，2型糖尿病患者中血管性痴呆的患病率可能较高。然而，由于简易精神状态检查表对痴呆敏感但对血管性痴呆不具有特异性，需要进一步进行涉及神经影像学和神经学检查的研究，以充分阐明蒙古人群中2型糖尿病与血管性痴呆之间的联系。
