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生物相容性材料在糖尿病伤口治疗中的应用研究进展

[Research advances on the application of biocompatible materials in treating diabetic wounds].

作者信息

Liu K T, Hu D H

机构信息

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

出版信息

Zhonghua Shao Shang Za Zhi. 2021 Sep 20;37(9):889-894. doi: 10.3760/cma.j.cn501120-20200619-00316.

DOI:10.3760/cma.j.cn501120-20200619-00316
PMID:34645157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11917365/
Abstract

At present, a variety of biocompatible materials have been applied in treating diabetic wounds, and some biocompatible materials have played an important role. Although biocompatible materials have advantages such as decreasing exposure and tension of wounds, and providing microenvironment to stimulate cell proliferation and migration, they also have disadvantages such as unstable effects and unclear mechanism. Therefore, this article reviews the recent advances on the biocompatible materials for the treatment of diabetic wounds, and discusses the possible development directions in the field of biocompatible materials.

摘要

目前,多种生物相容性材料已应用于糖尿病伤口的治疗,一些生物相容性材料发挥了重要作用。尽管生物相容性材料具有减少伤口暴露和张力、提供刺激细胞增殖和迁移的微环境等优点,但它们也存在效果不稳定、机制不明确等缺点。因此,本文综述了生物相容性材料治疗糖尿病伤口的最新进展,并探讨了生物相容性材料领域可能的发展方向。

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本文引用的文献

1
Fetal bovine acellular dermal matrix for the closure of diabetic foot ulcers: a prospective randomised controlled trial.胎儿牛去细胞真皮基质治疗糖尿病足溃疡:一项前瞻性随机对照试验。
J Wound Care. 2021 Jul 1;30(Sup7):S18-S27. doi: 10.12968/jowc.2021.30.Sup7.S18.
2
A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes.一种同时递送抗菌肽和富血小板血浆的复合水凝胶,以促进糖尿病感染伤口的愈合。
Acta Biomater. 2021 Apr 1;124:205-218. doi: 10.1016/j.actbio.2021.01.046. Epub 2021 Jan 30.
3
Injectable Hypoxia-Induced Conductive Hydrogel to Promote Diabetic Wound Healing.可注射缺氧诱导导电水凝胶促进糖尿病创面愈合。
ACS Appl Mater Interfaces. 2020 Dec 23;12(51):56681-56691. doi: 10.1021/acsami.0c13197. Epub 2020 Dec 4.
4
Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice.真皮基质、人间质干细胞和噻吗洛尔的组合产品可促进小鼠糖尿病伤口愈合。
Stem Cells Transl Med. 2020 Nov;9(11):1353-1364. doi: 10.1002/sctm.19-0380. Epub 2020 Jul 28.
5
Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p.负载利拉鲁肽的聚乳酸-羟基乙酸共聚物/明胶电纺纳米纤维垫通过调节miR-29b-3p促进血管生成,加速糖尿病伤口愈合。
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Development of Satureja cuneifolia-loaded sodium alginate/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material.通过3D打印技术制备的富含楔叶香薷的海藻酸钠/聚乙二醇支架作为糖尿病伤口敷料材料的研发。
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Biomaterials. 2020 Aug;249:120020. doi: 10.1016/j.biomaterials.2020.120020. Epub 2020 Apr 13.
8
Improved Diabetic Wound Healing by EGF Encapsulation in Gelatin-Alginate Coacervates.通过将表皮生长因子包裹于明胶-海藻酸盐凝聚层中来改善糖尿病伤口愈合。
Pharmaceutics. 2020 Apr 8;12(4):334. doi: 10.3390/pharmaceutics12040334.
9
A highly bioactive bone extracellular matrix-biomimetic nanofibrous system with rapid angiogenesis promotes diabetic wound healing.一种具有快速血管生成能力的高生物活性骨细胞外基质仿生纳米纤维系统可促进糖尿病伤口愈合。
J Mater Chem B. 2017 Sep 21;5(35):7285-7296. doi: 10.1039/c7tb01484h. Epub 2017 Aug 7.
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Topical α-gal nanoparticles accelerate diabetic wound healing.局部 α-半乳糖纳米颗粒加速糖尿病伤口愈合。
Exp Dermatol. 2020 Apr;29(4):404-413. doi: 10.1111/exd.14084. Epub 2020 Mar 1.