Meng G L, Wang Q, Kang R, Niu D, Xing N, Xie Y
Department of Clinical Laboratory, Northwest Women's and Children's Hospital, Xi'an 710061, China.
Department of Clinical Laboratory, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710069, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Feb 6;55(2):266-270. doi: 10.3760/cma.j.cn112150-20200617-00895.
To establish reference intervals for thyroid functional indicators in early (T1), mid-term (T2), and late stage (T3) pregnancy in a population of women in Northwestern China. A cross-sectional study was conducted on 620 pregnant women. Subjects were recruited through a questionnaire where apparently healthy women were selected. Serum thyroid stimulating hormone (TSH3), total triiodothyronine (TT3), total thyroid hormone (TT4), free triiodothyronine (FT3), and free thyroid hormone (FT4) were detected using the Beckman Unicel DXI 800 automatic chemiluminescence analyzer (the third-generation TSH detection reagent for TSH3),and the reference intervals of different gestation periods were established. The results showed that the reference intervals of TSH3 in T1, T2, and T3 were 0.05-4.59, 0.61-6.01, and 0.63-4.78 mIU/L, respectively; TT3 were 1.62-2.97 nmol/L, 1.59-2.95 nmol/L, and 1.45-2.70 nmol/L, respectively; TT4 were 95.49-185.00 nmol/L, 92.70-181.54 nmol/L, and 77.93-155.09 nmol/L, respectively; FT3 were 3.18-5.22 pmol/L, 2.78-4.67 pmol/L, and 2.51-4.18 pmol/L, respectively; and FT4 were 7.72-12.97 pmol/L, 6.90-1.09 pmol/L, and 5.63-9.85 pmol/L, respectively. All thyroid function indexes had statistically significant differences between the three stages of pregnancy (TSH:=30.879,<0.01;FT3: =153.827,<0.01;FT4: =229.967,<0.01;TT3: =36.484,<0.01;TT4: =58.531,<0.01). 20 independent samples were collected to verify the reference intervals of TSH, FT3, FT4, TT3 and TT4 for three trimesters of pregnancy, and all of them passed.
建立中国西北地区女性人群妊娠早期（T1）、中期（T2）及晚期（T3）甲状腺功能指标的参考区间。对620名孕妇进行了一项横断面研究。通过问卷调查招募受试者，选取表面健康的女性。使用贝克曼Unicel DXI 800全自动化学发光分析仪（用于TSH3的第三代TSH检测试剂）检测血清促甲状腺激素（TSH3）、总三碘甲状腺原氨酸（TT3）、总甲状腺激素（TT4）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺激素（FT4），并建立不同妊娠期的参考区间。结果显示，TSH3在T1、T2和T3期的参考区间分别为0.05 - 4.59、0.61 - 6.01及0.63 - 4.78 mIU/L；TT3分别为1.62 - 2.97 nmol/L、1.59 - 2.95 nmol/L及1.45 - 2.70 nmol/L；TT4分别为95.49 - 185.00 nmol/L、92.70 - 181.54 nmol/L及77.93 - 155.09 nmol/L；FT3分别为3.18 - 5.22 pmol/L、2.78 - 4.67 pmol/L及2.51 - 4.18 pmol/L；FT4分别为7.72 - 12.97 pmol/L、6.90 - 1.09 pmol/L及5.63 - 9.85 pmol/L。所有甲状腺功能指标在妊娠三个阶段之间均有统计学显著差异（TSH：=30.879, <0.01；FT3：=153.827, <0.01；FT4：=229.967, <0.01；TT3：=36.484, <0.01；TT4：=58.531, <0.01）。收集20个独立样本验证妊娠三期TSH、FT3、FT4、TT3及TT4的参考区间，结果均通过验证。
