Gati L J, Wiebe L I, Tse J W, Turner C J, Noujaim A A
Int J Rad Appl Instrum B. 1986;13(3):253-5. doi: 10.1016/0883-2897(86)90104-2.
67Ga citrate and 99mTc citrate (Solcocitran) were injected sequentially, with an interval of 48 h, into Balb/c mice bearing transplanted EMT-6 tumors. Tissue distributions of 67Ga and 99mTc were measured simultaneously at intervals of 1, 3, 5 and 8 h after injection of the 99mTc citrate (49, 51, 53 and 56 h after 67Ga citrate). Maximal tumor:blood ratios for 67Ga and 99mTc were 13.8 +/- 3.2 and 4.0 +/- 1.0 respectively, both occurring at the final period. The maximum tumor index (T.I. = T:B X % dose/g) for 67Ga was 71 +/- 23% 56 h after injection, and for 99mTc was 13 +/- 12% 1 h after injection. Liver, kidney and spleen had equal or higher concentrations of radioactivity than tumor for either radiotracer. The somewhat higher tumor:blood ratio for 67Ga citrate was offset by the time required for this optimum to be reached. Alternatively, the best 99mTc citrate tumor:blood ratios were attained within 8 h, with less liver and gut radioactivity. These data fall within the range of results from other clinical and animal model studies of 67Ga citrate and 99mTc citrate. In view of the radiation dose, the inconvenience of the 48-72 h wait, and the cost of 67Ga, and because neither radiopharmaceutical is tumor specific, 99mTc citrate may have a place in early oncological screening. The results are discussed as part of a comprehensive review of the 99mTc citrate literature.
将67Ga柠檬酸盐和99mTc柠檬酸盐（Solcocitran）以48小时的间隔依次注射到荷有移植EMT - 6肿瘤的Balb/c小鼠体内。在注射99mTc柠檬酸盐后1、3、5和8小时（即注射67Ga柠檬酸盐后49、51、53和56小时）同时测量67Ga和99mTc的组织分布。67Ga和99mTc的最大肿瘤与血液比值分别为1(.)8±3(.)2和4(.)0±1(.)0，均在最后阶段出现。67Ga的最大肿瘤指数（T.I. = T:B×%剂量/克）在注射后56小时为71±23%，99mTc的最大肿瘤指数在注射后1小时为13±12%。对于这两种放射性示踪剂，肝脏、肾脏和脾脏中的放射性浓度与肿瘤相等或更高。67Ga柠檬酸盐稍高的肿瘤与血液比值被达到最佳值所需的时间所抵消。相比之下，99mTc柠檬酸盐在8小时内达到最佳肿瘤与血液比值，肝脏和肠道的放射性较低。这些数据在其他关于67Ga柠檬酸盐和99mTc柠檬酸盐的临床和动物模型研究结果范围内。鉴于辐射剂量、48 - 72小时等待的不便以及67Ga的成本，并且由于这两种放射性药物都不是肿瘤特异性的，99mTc柠檬酸盐可能在早期肿瘤筛查中占有一席之地。作为对99mTc柠檬酸盐文献全面综述的一部分，对结果进行了讨论。
