Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, School of Primary and Allied Health Care, Monash University, Frankston, Australia.
Institute for Breathing and Sleep, Austin Health, Heidelberg, Australia.
Immun Inflamm Dis. 2022 Jan;10(1):101-110. doi: 10.1002/iid3.547. Epub 2021 Oct 14.
Chronic rhinosinusitis affects 62% of adults with bronchiectasis and is linked to greater bronchiectasis severity. However, the impact of symptoms of chronic rhinosinusitis on disease-specific and cough-related quality of life is unknown.
In this cross-sectional study, adults with stable bronchiectasis and chronic rhinosinusitis symptoms completed the sinonasal outcome test-22 (SNOT-22), quality of life-bronchiectasis questionnaire, and Leicester cough questionnaire. Bronchiectasis severity was assessed using the bronchiectasis severity index (BSI) and chest high-resolution computed tomography (HRCT).
Sixty participants with bronchiectasis (mean [SD] forced expiratory volume in 1 s of 73.2 [25.5] %predicted) were included. Greater severity of chronic rhinosinusitis symptoms (based on SNOT-22) was moderately associated with impaired cough-related quality of life (according to the Leicester cough questionnaire; all r > -.60) and impaired bronchiectasis-specific quality of life (based on the quality of life-bronchiectasis questionnaire), with impaired physical function (r = -.518), less vitality (r = -.631), reduced social function (r = -.546), greater treatment burden (r = -.411), and increased severity of respiratory symptoms (r = -.534). Chronic rhinosinusitis symptoms were unrelated to disease severity according to the BSI (r = .135) and HRCT scoring (all r < .200). The severity of chronic rhinosinusitis symptoms was not affected by sputum color (p = .417) or the presence of Pseudomonas aeruginosa colonization (p = .73).
In adults with bronchiectasis, chronic rhinosinusitis has a consistent and negative impact on both cough-related and bronchiectasis-specific quality of life.
慢性鼻-鼻窦炎影响 62%的支气管扩张症成人患者，且与支气管扩张症严重程度相关。然而，慢性鼻-鼻窦炎症状对特定疾病和咳嗽相关生活质量的影响尚不清楚。
在这项横断面研究中，有稳定支气管扩张症和慢性鼻-鼻窦炎症状的成年人完成了鼻-鼻窦结局测试-22（SNOT-22）、支气管扩张症生活质量问卷和莱斯特咳嗽问卷。支气管扩张症严重程度采用支气管扩张症严重指数（BSI）和胸部高分辨率计算机断层扫描（HRCT）进行评估。
共纳入 60 例支气管扩张症患者（平均[标准差]用力呼气量占预计值的 73.2[25.5]%）。慢性鼻-鼻窦炎症状严重程度（基于 SNOT-22）与咳嗽相关生活质量受损（根据莱斯特咳嗽问卷；所有 r >-.60）和支气管扩张症特定生活质量受损（基于生活质量-支气管扩张症问卷）具有中度相关性，与身体机能受损（r =-.518）、活力降低（r =-.631）、社会功能下降（r =-.546）、治疗负担增加（r =-.411）和呼吸症状严重程度增加（r =-.534）相关。根据 BSI（r =.135）和 HRCT 评分（所有 r <.200），慢性鼻-鼻窦炎症状与疾病严重程度无关。慢性鼻-鼻窦炎症状的严重程度不受痰液颜色（p =.417）或铜绿假单胞菌定植（p =.73）的影响。
在支气管扩张症成人患者中，慢性鼻-鼻窦炎对咳嗽相关和支气管扩张症特定生活质量均有持续且负面的影响。
