Department of Psychological and Brain Sciences, Rajen Kilachand Center for Integrated Life Sciences and Engineering, Boston University, Boston, United States.
Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, Canada.
Elife. 2021 Oct 14;10:e68795. doi: 10.7554/eLife.68795.
Envisioning the future is intuitively linked to our ability to remember the past. Within the memory system, substantial work has demonstrated the involvement of the prefrontal cortex and the hippocampus in representing the past and present. Recent data shows that both the prefrontal cortex and the hippocampus encode future trajectories, which are segregated in time by alternating cycles of the theta rhythm. Here, we discuss how information is temporally organized by these brain regions supported by the medial septum, nucleus reuniens, and parahippocampal regions. Finally, we highlight a brain circuit that we predict is essential for the temporal segregation of future scenarios.
展望未来与我们回忆过去的能力有着直观的联系。在记忆系统中，大量的研究已经证明了前额叶皮层和海马体在代表过去和现在方面的参与。最近的数据表明，前额叶皮层和海马体都对未来轨迹进行编码，这些轨迹通过交替的θ节律循环在时间上分开。在这里，我们讨论了这些脑区如何在中隔核、 reunens 核和海马旁回等内侧隔核、 reunens 核和海马旁回的支持下，对信息进行时间组织。最后，我们强调了一个我们预测对于未来场景的时间分离至关重要的大脑回路。
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