UCL Institute of Ophthalmology, University College London, London, UK.
Population, Policy and Practice Department of Research and Teaching, UCL GOS Institute of Child Health, London, UK.
Ocul Immunol Inflamm. 2022 Oct-Nov;30(7-8):1931-1935. doi: 10.1080/09273948.2021.1976215. Epub 2021 Oct 14.
We describe an investigation of temporal trends in the incidence of childhood uveitis-related hospital admissions, hospitalization being a robust indicator of disease severity.
A population-based retrospective study using a hospitalization database, the Hospital Episode Statistics (HES) dataset, capturing data on care between 2013 and 2020. Primary outcomes were rates of pediatric hospital admissions for uveitis-related disorders.
During the study period, there were 3,258 reported uveitis-related hospital admissions of children aged 0 to 14 years, comprising 19% of all-age uveitis-related admissions. Anterior uveitis was the most common diagnosis. The annual incidence of childhood uveitis-related hospitalizations declined year on year from a peak incidence of 5.4 per 100,000 children (95% confidence interval 5.0-5.9) in 2015-2016 to 3.3 per 100,000 (95% CI 3.0-3.6) in 2019-2020. Over the same period, the national incidence of juvenile arthropathy-related admissions stayed stable.
The decline in admissions nationally may reflect reduced incidence of uveitis complications with increasing use of immunosuppressive therapies.
我们描述了一项关于儿童葡萄膜炎相关住院发病率的时间趋势的调查，住院是疾病严重程度的一个有力指标。
这是一项基于人群的回顾性研究，使用了住院数据库（HES 数据集），该数据集记录了 2013 年至 2020 年期间的护理数据。主要结局是儿童葡萄膜炎相关疾病的住院率。
在研究期间，有 3258 例报告的儿童（0 至 14 岁）葡萄膜炎相关住院治疗，占所有年龄葡萄膜炎相关住院治疗的 19%。前葡萄膜炎是最常见的诊断。儿童葡萄膜炎相关住院的年发病率逐年下降，从 2015-2016 年的每 100,000 名儿童中 5.4 例（95%置信区间 5.0-5.9）的峰值降至 2019-2020 年的每 100,000 名儿童中 3.3 例（95%置信区间 3.0-3.6）。同期，全国青少年关节病相关住院率保持稳定。
全国范围内住院人数的下降可能反映了免疫抑制治疗的使用增加，从而减少了葡萄膜炎并发症的发生。
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