Renal, Electrolyte-Hypertension Division, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Geisinger Commonwealth School of Medicine, Scranton, PA.
J Ren Nutr. 2022 Jan;32(1):39-50. doi: 10.1053/j.jrn.2021.08.006. Epub 2021 Oct 11.
The aim of this study is to examine the effect of a telehealth intervention that used a dietary app, educational website, and weekly dietitian tele-counseling on sodium intake, diet quality, blood pressure, and albuminuria among individuals with diabetes and early-stage chronic kidney disease.
We examined the effects of a dietary app-supported tele-counseling intervention in a single center, single arm study of 44 participants with type 2 diabetes and stage 1-3a chronic kidney disease. Participants recorded and shared dietary data via MyFitnessPal with registered dietitians, who used motivational interviewing to provide telephone counseling weekly for 8 weeks. After the 8-week intensive intervention, participants were followed at 6 and 12 months. Outcomes included 24-hour urine sodium (2 collections per timepoint), Healthy Eating Index 2015 score (three 24-hour dietary recalls per timepoint), 24-hour systolic blood pressure (SBP) and diastolic blood pressure (DBP), and 24-hour urine albumin excretion.
Out of 44 consented participants (mean age 60.3 ± 11.9 years, 43% female, 89% white, median estimated glomerular filtration rate was 78.5 mL/min/1.73 m, median urine albumin excretion 52.9 mg/day, 84% hypertension), 32 (73%) completed 8-week follow-up, 27 (61%) completed 6-month follow-up, and 25 (57%) completed 12-month follow-up. Among participants who completed 12-month follow-up, reported sodium intake decreased by 638 mg/day from baseline of 2,919 mg/day (P < .001). The 24-hour mean urine sodium and albumin excretion did not decline over the study period. Healthy Eating Index 2015 score improved by 7.76 points at 12 months from a mean baseline of 54.6 (P < .001). Both 24-hour SBP and DBP declined at 12 months from baseline (SBP -5.7 mm Hg, 95% confidence interval -10.5 to -1.0, P = .02; DBP -4.1 mm Hg, 95% confidence interval -7.2 to -1.1, P = .01).
Overall, this study demonstrates that a short, intensive, remotely delivered dietary intervention for adults with type 2 diabetes and early chronic kidney disease at high risk for disease progression and cardiovascular complications led to improvement in blood pressure and self-reported sodium intake and diet quality, but no improvement in albuminuria. Future research studies are needed to examine whether remotely delivered dietary interventions can ultimately improve kidney health over time.
本研究旨在探讨一种基于饮食应用程序、教育网站和每周营养师远程咨询的远程医疗干预措施对糖尿病合并早期慢性肾脏病患者钠摄入量、饮食质量、血压和白蛋白尿的影响。
我们在一项单中心、单臂研究中,对 44 名患有 2 型糖尿病和 1-3a 期慢性肾脏病的患者进行了饮食应用程序支持的远程咨询干预效果的评估。参与者通过 MyFitnessPal 记录和共享饮食数据,注册营养师使用动机访谈每周提供电话咨询 8 周。在 8 周的强化干预后,参与者在 6 个月和 12 个月时进行随访。结果包括 24 小时尿钠(每个时间点采集 2 次)、2015 年健康饮食指数评分(每个时间点采集 3 次 24 小时膳食回忆)、24 小时收缩压和舒张压以及 24 小时尿白蛋白排泄。
在 44 名同意参与的患者中(平均年龄 60.3±11.9 岁,43%为女性,89%为白人,估计肾小球滤过率中位数为 78.5ml/min/1.73m,中位数尿白蛋白排泄量为 52.9mg/天,84%患有高血压),32 名(73%)完成了 8 周随访,27 名(61%)完成了 6 个月随访,25 名(57%)完成了 12 个月随访。在完成 12 个月随访的参与者中,报告的钠摄入量从基线的 2919mg/天减少了 638mg/天(P<.001)。在研究期间,24 小时平均尿钠和白蛋白排泄量没有下降。健康饮食指数 2015 评分在 12 个月时从平均基线的 54.6 分提高了 7.76 分(P<.001)。24 小时收缩压和舒张压在 12 个月时均较基线下降(收缩压-5.7mmHg,95%置信区间-10.5 至-1.0,P=0.02;舒张压-4.1mmHg,95%置信区间-7.2 至-1.1,P=0.01)。
总体而言,本研究表明,针对 2 型糖尿病合并早期慢性肾脏病且有疾病进展和心血管并发症高风险的成年人进行短期、强化、远程提供的饮食干预措施可改善血压和自我报告的钠摄入量和饮食质量,但对白蛋白尿无改善。需要进一步的研究来探讨远程提供的饮食干预措施是否最终能随着时间的推移改善肾脏健康。