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拒绝常规癌症治疗的肺癌患者:自行使用“大麻二酚油”是否有助于观察到肿瘤消退?

Lung cancer patient who had declined conventional cancer treatment: could the self-administration of 'CBD oil' be contributing to the observed tumour regression?

机构信息

Respiratory Department, Watford General Hospital, Watford, UK

Radiology Department, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.

出版信息

BMJ Case Rep. 2021 Oct 14;14(10):e244195. doi: 10.1136/bcr-2021-244195.

Abstract

Conventional lung cancer treatments include surgery, chemotherapy and radiotherapy; however, these treatments are often poorly tolerated by patients. Cannabinoids have been studied for use as a primary cancer treatment. Cannabinoids, which are chemically similar to our own body's endocannabinoids, can interact with signalling pathways to control the fate of cells, including cancer cells. We present a patient who declined conventional lung cancer treatment. Without the knowledge of her clinicians, she chose to self-administer 'cannabidiol (CBD) oil' orally 2-3 times daily. Serial imaging shows that her cancer reduced in size progressively from 41 mm to 10 mm over a period of 2.5 years. Previous studies have failed to agree on the usefulness of cannabinoids as a cancer treatment. This case appears to demonstrate a possible benefit of 'CBD oil' intake that may have resulted in the observed tumour regression. The use of cannabinoids as a potential cancer treatment justifies further research.

摘要

传统的肺癌治疗方法包括手术、化疗和放疗;然而,这些治疗方法往往让患者难以耐受。大麻素已被研究用于癌症的主要治疗。大麻素在化学上与我们体内的内源性大麻素相似,可与信号通路相互作用,控制包括癌细胞在内的细胞的命运。我们介绍了一位拒绝接受传统肺癌治疗的患者。在她的临床医生不知情的情况下,她选择自行口服“大麻二酚(CBD)油”,每天 2-3 次。连续的影像学检查显示,她的癌症在 2.5 年内从 41 毫米逐渐缩小到 10 毫米。以前的研究未能就大麻素作为癌症治疗的有效性达成一致。这个病例似乎表明,摄入“大麻二酚(CBD)油”可能带来了肿瘤消退的益处。大麻素作为一种潜在的癌症治疗方法值得进一步研究。

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