Respiratory Department, Watford General Hospital, Watford, UK
Radiology Department, Basildon and Thurrock University Hospitals NHS Foundation Trust, Basildon, UK.
BMJ Case Rep. 2021 Oct 14;14(10):e244195. doi: 10.1136/bcr-2021-244195.
Conventional lung cancer treatments include surgery, chemotherapy and radiotherapy; however, these treatments are often poorly tolerated by patients. Cannabinoids have been studied for use as a primary cancer treatment. Cannabinoids, which are chemically similar to our own body's endocannabinoids, can interact with signalling pathways to control the fate of cells, including cancer cells. We present a patient who declined conventional lung cancer treatment. Without the knowledge of her clinicians, she chose to self-administer 'cannabidiol (CBD) oil' orally 2-3 times daily. Serial imaging shows that her cancer reduced in size progressively from 41 mm to 10 mm over a period of 2.5 years. Previous studies have failed to agree on the usefulness of cannabinoids as a cancer treatment. This case appears to demonstrate a possible benefit of 'CBD oil' intake that may have resulted in the observed tumour regression. The use of cannabinoids as a potential cancer treatment justifies further research.
传统的肺癌治疗方法包括手术、化疗和放疗;然而,这些治疗方法往往让患者难以耐受。大麻素已被研究用于癌症的主要治疗。大麻素在化学上与我们体内的内源性大麻素相似,可与信号通路相互作用,控制包括癌细胞在内的细胞的命运。我们介绍了一位拒绝接受传统肺癌治疗的患者。在她的临床医生不知情的情况下,她选择自行口服“大麻二酚(CBD)油”,每天 2-3 次。连续的影像学检查显示,她的癌症在 2.5 年内从 41 毫米逐渐缩小到 10 毫米。以前的研究未能就大麻素作为癌症治疗的有效性达成一致。这个病例似乎表明,摄入“大麻二酚(CBD)油”可能带来了肿瘤消退的益处。大麻素作为一种潜在的癌症治疗方法值得进一步研究。