Chiang Chun-Yen, Chen Chin-Yu, Yu Wen-Liang, Kan Wei-Chih, Feng Yin-Hsun
Department of Cardiology, Chi Mei Medical Center, Tainan, TWN.
Department of Optometry, Chung Hwa University of Medical Technology, Tainan, TWN.
Cureus. 2021 Sep 30;13(9):e18390. doi: 10.7759/cureus.18390. eCollection 2021 Sep.
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication after vaccination of Oxford-AstraZeneca coronavirus disease 2019 (COVID-19) vaccine (AZD1222) or Janssen COVID-19 vaccine. It makes a rare complication of thrombosis at common and/or uncommon organs with thrombocytopenia after COVID-19 vaccination four to 28 days later and most patients were younger than 60 years of age. We reported the case of a 75-year-old female with end-stage renal disease who received regular hemodialysis. She received Oxford-AstraZeneca COVID-19 vaccination eight days ago and then she suffered from intermittent chest tightness and epigastric pain with tarry stool passage for two days. Severe thrombocytopenia with elevated D-dimer value was noted and computed tomography of the chest showed azygos vein thrombosis. Elevated cardiac enzyme with ST-T change in 12-lead electrocardiogram was also noted. For positive anti-platelet factor 4 antibodies, VITT with myocardial infarction and azygos vein thrombosis was diagnosed.
疫苗诱导的免疫性血栓性血小板减少症(VITT)是接种牛津-阿斯利康2019冠状病毒病(COVID-19)疫苗(AZD1222)或杨森COVID-19疫苗后罕见的并发症。它是COVID-19疫苗接种四至28天后在常见和/或不常见器官发生血栓形成并伴有血小板减少的罕见并发症,大多数患者年龄小于60岁。我们报告了一例75岁终末期肾病女性患者的病例,该患者接受定期血液透析。她于八天前接种了牛津-阿斯利康COVID-19疫苗,随后出现间歇性胸闷、上腹部疼痛并伴有柏油样便两天。检查发现严重血小板减少且D-二聚体值升高,胸部计算机断层扫描显示奇静脉血栓形成。12导联心电图还显示心肌酶升高伴ST-T改变。由于抗血小板因子4抗体呈阳性,诊断为VITT合并心肌梗死和奇静脉血栓形成。