Luo Xing, Lv Ying, Bai Xiaoxuan, Qi Jinyu, Weng Xiuzhu, Liu Shaoyu, Bao Xiaoyi, Jia Haibo, Yu Bo
Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China.
Front Cardiovasc Med. 2021 Sep 28;8:711453. doi: 10.3389/fcvm.2021.711453. eCollection 2021.
Plaque erosion (PE) is one of the most important pathological mechanisms underlying acute coronary syndrome (ACS). The incidence of PE is being increasingly recognized owing to the development and popularization of intracavitary imaging. Unlike traditional vulnerable plaques, eroded plaques have unique pathological characteristics. Moreover, recent studies have revealed that there are differences in the physiopathological mechanisms, biomarkers, and clinical outcomes between PE and plaque rupture (PR). Accurate diagnosis and treatment of eroded plaques require an understanding of the pathogenesis of PE. In this review, we summarize recent scientific discoveries of the pathological characteristics, mechanisms, biomarkers, clinical strategies, and prognosis in patients with PE.
斑块侵蚀(PE)是急性冠状动脉综合征(ACS)最重要的病理机制之一。随着腔内成像技术的发展和普及,PE的发病率越来越受到认可。与传统的易损斑块不同,侵蚀性斑块具有独特的病理特征。此外,最近的研究表明,PE与斑块破裂(PR)在生理病理机制、生物标志物和临床结局方面存在差异。准确诊断和治疗侵蚀性斑块需要了解PE的发病机制。在这篇综述中,我们总结了PE患者病理特征、机制、生物标志物、临床策略和预后的最新科学发现。