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香烟焦油通过钙调蛋白激酶II/动力相关蛋白1/线粒体DNA增强内皮细胞焦亡：对斑块侵蚀机制的新见解

Cigarette Tar Enhanced ECs Pyroptosis via CAMKII/Drp1/mtDNA: Novel Insight Into the Mechanism of Plaque Erosion.

作者信息

Luo Xing, Li Ji, Chen Yuwu, Weng Xiuzhu, Bao Xiaoyi, Bai Xiaoxuan, Lv Ying, Zhang Shan, Zhu Xinxin, Xu Biyi, Zhao Chen, Zeng Ming, Wu Tianyu, Sun Qianhui, Wang Shengfang, Liu Minghao, Johnson Thomas, White Stephen J, Libby Peter, Hu Sining, Yu Bo, Jia Haibo

机构信息

Department of Cardiology of the Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Nangang District, Harbin, China; Key Laboratory of Myocardial Ischemia, Ministry of Education, Nangang District, Harbin, China.

Department of Cardiology, Bristol Heart Institute, Bristol, United Kingdom.

出版信息

JACC Basic Transl Sci. 2025 Aug;10(8):101283. doi: 10.1016/j.jacbts.2025.03.015.

DOI:10.1016/j.jacbts.2025.03.015
PMID:40866045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12399138/
Abstract

Smoking is the only cardiovascular risk factor for plaque erosion. We found cigarette tar resulted in erosion-like lesion development in apolipoprotein E mice, with mural thrombosis, discontinuous endothelium, platelet activation, smooth muscle cell proliferation, and hyaluronic acid accumulation in the aorta. Single-cell transcriptomics revealed that genes relating to pyroptosis, platelet activation, and leukocytes adhesion were significantly increased in an endothelial cell subset. Rescue assays indicated cigarette tar caused human coronary artery endothelial cell pyroptosis by enhanced calcium-calmodulin-dependent protein kinase II / dynamin-related protein 1-mediated mitochondrial fission and mitochondrial DNA release via activating Ca signaling. Inhibition of endothelial cell pyroptosis may be a novel therapeutic strategy to reduce plaque erosion.

摘要

吸烟是斑块侵蚀的唯一心血管危险因素。我们发现香烟焦油可导致载脂蛋白E小鼠出现类似侵蚀的病变，伴有主动脉壁血栓形成、内皮不连续、血小板活化、平滑肌细胞增殖和透明质酸积聚。单细胞转录组学显示，在内皮细胞亚群中，与细胞焦亡、血小板活化和白细胞黏附相关的基因显著增加。挽救实验表明，香烟焦油通过激活钙信号，增强钙调蛋白依赖性蛋白激酶II/动力相关蛋白1介导的线粒体分裂和线粒体DNA释放，从而导致人冠状动脉内皮细胞焦亡。抑制内皮细胞焦亡可能是减少斑块侵蚀的一种新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/282f5dda2563/gr7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/4f8c5c46e39e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/f829f7dfcdb5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/aee52930578b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/3492414f5bf9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/4c95fe94ac52/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/e045b9ed63df/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/0a3bbb2709b6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f35f/12399138/282f5dda2563/gr7.jpg

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本文引用的文献

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Cell Commun Signal. 2024 Jan 16;22(1):41. doi: 10.1186/s12964-024-01480-6.
2
Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway.香烟焦油通过血红素/铁转运蛋白/溶质载体家族 7 成员 11 信号通路介导动脉粥样硬化中的巨噬细胞铁死亡。
Free Radic Biol Med. 2023 May 20;201:76-88. doi: 10.1016/j.freeradbiomed.2023.03.006. Epub 2023 Mar 16.
3
A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion.
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Cardiovasc Res. 2023 Aug 7;119(9):1869-1882. doi: 10.1093/cvr/cvad022.
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BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils.BAM15 治疗小鼠脓毒症和肾损伤，将死亡率、线粒体 DNA、肾小管损伤和中性粒细胞联系起来。
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