Kastrup K W
Acta Endocrinol Suppl (Copenh). 1986;279:157-63. doi: 10.1530/acta.0.112s157.
Early therapy with a low dose of estrogen (estradiol-17 beta) was given to 33 girls with Turner's syndrome (T.s.) for a period of 4 years. The dose (0.25-2 mg/day) was adjusted every 3 months to maintain plasma estradiol in the normal concentration range for bone age. Growth velocity was compared with that of untreated girls with T.s. All girls were above age 10 years. Bone age was below 10 years in 11 girls (group I) and above 10 years in 22 girls (group II). Growth velocity in the first year of treatment in group I 7.5 +/- 1.3 cm (SD) with mean SD score (SDS) of +4.3 and in group II 4.9 +/- 1.3 with mean SDS of +3.5. Growth velocity decreased in the following years to 1.6 +/- 1.0 cm, SDS -1.44 in group I and 0.9 +/- 0.6 cm, SDS -2.34 in group II during the fourth year. Withdrawal bleeding occurred in 16 girls of group II after the mean of 23 (range 15-33) months and in 3 girls of group I after 15 to 51 months of treatment. The treatment did not cause an inappropriate acceleration of pubertal development. Breast development appeared in most girls by 3 months of treatment. Pubic hair appeared by 12 months of treatment in group I; it was present in most girls in group II at start of treatment. Final height is known for 12 girls of group II; it was 144.2 +/- 4.5 cm. The final height as predicted at the start of therapy was 142.2 +/- 5.3 cm.(ABSTRACT TRUNCATED AT 250 WORDS)
对33名特纳综合征（T.s.）女孩进行了为期4年的低剂量雌激素（雌二醇-17β）早期治疗。每3个月调整一次剂量（0.25 - 2毫克/天），以维持血浆雌二醇处于与骨龄相应的正常浓度范围。将生长速度与未接受治疗的T.s.女孩进行比较。所有女孩年龄均超过10岁。11名女孩（第一组）骨龄低于10岁，22名女孩（第二组）骨龄高于10岁。第一组治疗第一年的生长速度为7.5±1.3厘米（标准差），平均标准差评分（SDS）为+4.3，第二组为4.9±1.3，平均SDS为+3.5。在接下来的几年中，生长速度下降，第一组在第四年降至1.6±1.0厘米，SDS为-1.44，第二组降至0.9±0.6厘米，SDS为-2.34。第二组16名女孩在平均23个月（范围15 - 33个月）后出现撤退性出血，第一组3名女孩在治疗15至51个月后出现。该治疗未导致青春期发育的不适当加速。大多数女孩在治疗3个月时出现乳房发育。第一组女孩在治疗12个月时出现阴毛；第二组大多数女孩在治疗开始时就有阴毛。已知第二组12名女孩的最终身高；为144.2±4.5厘米。治疗开始时预测的最终身高为142.2±5.3厘米。（摘要截断于250字）
