Van der Werff ten Bosch J J, Bot A
Acta Endocrinol Suppl (Copenh). 1986;279:29-34. doi: 10.1530/acta.0.112s029.
Two male hypopituitary dwarfs were treated with human pituitary growth hormone (hGH) from the ages of 24.3 and 22.7 years, at bone ages of 13-14 years TW2-RUS. Height, weight, upper arm circumference and skinfolds, and skeletal maturation were studied during 1.7 and 2.2 years of hGH alone, followed by 3.1 and 3.0 years of hGH combined with exogenous androgen. Although height growth rate was doubled by hGH alone, actual growth during first year was only 2.2 and 3.5 cm. Addition of androgen caused growth rate of about 8 cm in first year, and total height gains of 17 and 16 cm. These figures are similar to those of normal late maturers, of hyposomatotropism with spontaneous puberty, and of hypogonadotropic hypogonadists receiving androgen. So at pubertal bone age hGH effect on height is largely dependent on presence of androgen, irrespective of chronological age. Arm fat and muscle underwent profound changes under influence of hGH alone (particularly fat) and with androgen (particularly muscle).
两名男性垂体功能减退侏儒症患者在24.3岁和22.7岁时开始接受人生长激素（hGH）治疗，当时他们的骨龄根据TW2-RUS法为13 - 14岁。在单独使用hGH的1.7年和2.2年期间，以及随后hGH与外源性雄激素联合使用的3.1年和3.0年期间，对患者的身高、体重、上臂围、皮褶厚度和骨骼成熟度进行了研究。尽管单独使用hGH可使身高生长速率翻倍，但第一年的实际生长仅为2.2厘米和3.5厘米。添加雄激素后，第一年的生长速率约为8厘米，总身高增加了17厘米和16厘米。这些数据与正常晚熟者、具有自发性青春期的生长激素缺乏症患者以及接受雄激素治疗的促性腺激素缺乏性性腺功能减退患者的数据相似。因此，在青春期骨龄时，hGH对身高的影响在很大程度上取决于雄激素的存在，而与实际年龄无关。单独使用hGH（尤其是对脂肪）以及与雄激素联合使用（尤其是对肌肉）时，手臂的脂肪和肌肉发生了显著变化。
