Young G A, Milliken S, Jurd J, Poulgrain P, Vincent P C
Aust N Z J Med. 1986 Jun;16(3):373-7. doi: 10.1111/j.1445-5994.1986.tb01190.x.
Between 1974 and 1982, 17 patients with central nervous system disease secondary to hematological malignancy had an intraventricular reservoir inserted to monitor their disease and to instill cytotoxic chemotherapy. Two other patients with acute lymphoblastic leukemia and difficult access to the cerebrospinal fluid had a reservoir inserted to facilitate intrathecal chemotherapy. All 17 patients with established disease showed clinical improvement. Thirteen patients had complete elimination of malignant cells from the cerebrospinal fluid with cytotoxic chemotherapy, and the other four had a reduction in the concentration of malignant cells. Infection and neurotoxicity were found in a significant number of cases, and therefore the good clinical response associated with the procedure must be weighed carefully against the associated toxicity.
1974年至1982年间，17例继发于血液系统恶性肿瘤的中枢神经系统疾病患者植入了脑室内储液器，以监测病情并注入细胞毒性化疗药物。另外两名急性淋巴细胞白血病患者因难以获取脑脊液而植入储液器，以方便鞘内化疗。所有17例确诊患者均有临床改善。13例患者通过细胞毒性化疗使脑脊液中的恶性细胞完全清除，另外4例患者的恶性细胞浓度有所降低。在相当多的病例中发现了感染和神经毒性，因此必须仔细权衡该操作带来的良好临床反应与相关毒性。
