March L M, Webb J, Eckstein R P
Aust N Z J Med. 1986 Jun;16(3):397-401. doi: 10.1111/j.1445-5994.1986.tb01197.x.
A 60 year old woman developed generalised erythema nodosum-like lesions together with hectic fever, lymphadenopathy, and hepatitis. Biopsies revealed lobular panniculitis with a benign histiocytic infiltrate and prominent phagocytosis in subcutaneous sites, lymph nodes, and bone marrow. All immunological, serological, and culture studies were negative, apart from throat isolation of herpes simplex. The patient responded to high-dose corticosteroids. The case illustrates the differential diagnosis of lobular panniculitis, with histiocytic infiltrate and cytophagocytosis. These combined features are consistent with the recently described syndromes of cytophagic panniculitis and virus-associated hemophagocytic syndrome.
一名60岁女性出现了全身性结节性红斑样皮损，同时伴有弛张热、淋巴结病和肝炎。活检显示小叶性脂膜炎，在皮下部位、淋巴结和骨髓中有良性组织细胞浸润及显著的吞噬作用。除从咽喉部分离出单纯疱疹外，所有免疫、血清学和培养研究均为阴性。患者对大剂量皮质类固醇治疗有反应。该病例说明了伴有组织细胞浸润和细胞吞噬作用的小叶性脂膜炎的鉴别诊断。这些综合特征与最近描述的噬血细胞性脂膜炎综合征和病毒相关噬血细胞综合征相符。
