School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
Biomed Chromatogr. 2022 Feb;36(2):e5267. doi: 10.1002/bmc.5267. Epub 2021 Nov 18.
To evaluate the residual levels of bifenthrin and dinotefuran, a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) and high-performance liquid chromatography-tandem mass spectrometry method for simultaneous detection of bifenthrin and dinotefuran and its major metabolites in wheat was developed and validated. Dietary risk assessments were further performed based on the relevant residual data from 12 wheat fields, toxicology data and dietary patterns. In wheat grain and straw, the recoveries of all analytes ranged from 77 to 102% with the relative standard deviation <9.7% and the limit of quantitation 0.05 mg kg . The highest terminal residue of bifenthrin in wheat grain was 0.069 mg kg and dinotefuran was 0.34 mg kg . Residual concentrations of bifenthrin and dinotefuran decreased to <0.05 and 0.15 mg kg at 21 days (pre-harvest interval), respectively. The chronic risk quotient ranged from 6.4 to 62.7% and the acute risk quotient varied from 0.38 to 17.73%. The chronic and acute dietary risks caused by the terminal residues of the two insecticides were negligible for Chinese populations. The recommended pre-harvest interval was proposed to ensure safe wheat consumption. These data could provide a scientific reference to establish the Chinese maximum residue limit of dinotefuran in wheat.
为了评估联苯菊酯和呋虫胺的残留水平，建立并验证了一种改良的快速、简便、廉价、有效、耐用和安全（QuEChERS）的高效液相色谱-串联质谱法，用于同时检测小麦中联苯菊酯和呋虫胺及其主要代谢物。基于 12 个麦田的相关残留数据、毒理学数据和饮食模式，进一步进行了膳食风险评估。在小麦籽粒和秸秆中，所有分析物的回收率在 77%至 102%之间，相对标准偏差<9.7%，定量限为 0.05mg/kg。小麦籽粒中联苯菊酯的最高终端残留量为 0.069mg/kg，呋虫胺为 0.34mg/kg。在 21 天（收获前间隔）时，联苯菊酯和呋虫胺的残留浓度分别降至<0.05 和 0.15mg/kg。慢性风险商数范围为 6.4%至 62.7%，急性风险商数范围为 0.38 至 17.73%。这两种杀虫剂的终端残留对中国人群造成的慢性和急性膳食风险可以忽略不计。建议的收获前间隔时间可确保小麦安全食用。这些数据可为制定中国小麦中呋虫胺的最大残留限量提供科学参考。
