Analysis Center, Residue Laboratory, Jiangsu Evertest Co., Ltd, Nanjing, China.
J Sci Food Agric. 2021 Nov;101(14):5842-5850. doi: 10.1002/jsfa.11236. Epub 2021 Apr 14.
Flonicamid and dinotefuran are widely applied to control pests and diseases in various economic crops arousing much public concerns about the potential risk to human health. In this study, the multi-determination and residual behavior of flonicamid-dinotefuran mixture on peach trees were investigated. The chronic risk of long-term dietary intake for Chinese consumers was evaluated.
An optimized QuEChERS method combined with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis for simultaneous determination of flonicamid, dinotefuran and its metabolites was established to analyze the residual dissipation and terminal residues in peach matrices. The results demonstrated that (i) a satisfactory linearity relationship with the detector response and the correlation coefficient R > 0.999, the average recoveries of these four analytes ranged from 94 to 108%, the relative standard deviation was between 1.0% and 8.8%, and the limit of the quantitation was 0.02 mg kg ; (ii) the dissipation behaviors of flonicamid and dinotefuran followed with the first-order dynamic kinetics model, and the half-lives were 6.9-12.4 days and 8.1-15.1 days, respectively; (iii) the recommended preharvest interval (PHI) was 21 days, the risk quotient (RQ) values of flonicamid and dinotefuran were 16.6 and 20.7%, respectively, which were significantly less than 100%.
The established analytical method met the detection requirement in terms of sensitivity, accuracy, and precision. Additionally, the results indicated that the potential dietary intake risk of the flonicamid-dinotefuran mixture on peach trees was negligible. This work can be utilized in the safe and responsible use of flonicamid-dinotefuran mixture and provide guidance for establishing its maximum residue limit (MRL) in China. © 2021 Society of Chemical Industry.
氟啶虫酰胺和噻虫嗪广泛应用于控制各种经济作物的病虫害，这引起了人们对其对人类健康潜在风险的极大关注。本研究调查了氟啶虫酰胺-噻虫嗪混合物在桃树上的多残留行为和残留行为，并评估了中国消费者长期饮食摄入的慢性风险。
建立了一种优化的 QuEChERS 方法，结合超高效液相色谱-串联质谱（UPLC-MS/MS）分析，用于同时测定桃基质中的氟啶虫酰胺、噻虫嗪及其代谢物。结果表明：（i）检测响应与相关系数 R 均具有令人满意的线性关系，＞0.999，这四种分析物的平均回收率在 94%至 108%之间，相对标准偏差在 1.0%至 8.8%之间，定量限为 0.02mg/kg；（ii）氟啶虫酰胺和噻虫嗪的消解行为符合一级动力学模型，半衰期分别为 6.9-12.4 天和 8.1-15.1 天；（iii）推荐的采收前间隔（PHI）为 21 天，氟啶虫酰胺和噻虫嗪的风险商（RQ）值分别为 16.6%和 20.7%，均显著低于 100%。
所建立的分析方法在灵敏度、准确性和精密度方面均符合检测要求。此外，结果表明，桃树施用氟啶虫酰胺-噻虫嗪混合物的潜在膳食摄入风险可以忽略不计。本工作可用于安全、负责任地使用氟啶虫酰胺-噻虫嗪混合物，并为在中国建立其最大残留限量（MRL）提供指导。© 2021 化学工业协会。
