细颗粒物 2.5 对肝细胞癌风险的影响：一项荟萃分析。
The impact of particulate matter 2.5 on the risk of hepatocellular carcinoma: a meta-analysis.
机构信息
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
出版信息
Int Arch Occup Environ Health. 2022 Apr;95(3):677-683. doi: 10.1007/s00420-021-01773-0. Epub 2021 Oct 15.
OBJECTIVE
The convoluted element of PM2.5 may cause various biological reactions. Nowadays, few studies have indicated the long-term health effects of PM2.5 on HCC. Therefore, this meta-analysis first aims to obtain more precise estimates of the effects of PM2.5 exposure on HCC to assess the strength of the evidence.
METHODS
A combination of computer and manual retrieval was used to search in Medline through PubMed, EMBASE and Web of Science. Review Manager 5.3 software was used to examine the heterogeneity among the studies.
RESULTS
Finally, 8 qualified articles meet the inclusion criteria. The results were I = 0%, P > 0.1 indicating that there was no heterogeneity. The results showed that the concentration of PM2.5 increased by 10 μg/m was significantly correlated with liver cancer, and HR was 1.22 (95% CI 1.14-1.30, P < 0.05), indicating that maternal exposure to PM2.5 was positively correlated with liver cancer.
CONCLUSIONS
Our meta-analysis showed that the patients with HCC significance related to PM2.5 exposure. However, more studies investigating the combined effects of different air pollutants on HCC incidence are warranted to provide more comprehensive evidence for assessing the different levels impacts of PM2.5 exposure on HCC incidence.
目的
PM2.5 的复杂成分可能会引起各种生物反应。目前，很少有研究表明 PM2.5 对 HCC 的长期健康影响。因此，本荟萃分析首先旨在获得更精确的 PM2.5 暴露对 HCC 影响的估计值，以评估证据的强度。
方法
采用计算机检索和手工检索相结合的方法，在 Medline 通过 PubMed、EMBASE 和 Web of Science 进行检索。使用 Review Manager 5.3 软件检验研究间的异质性。
结果
最终有 8 篇符合纳入标准的文章。结果为 I = 0%，P > 0.1，表明无异质性。结果表明，PM2.5 浓度增加 10μg/m 与肝癌显著相关，HR 为 1.22（95% CI 1.14-1.30，P < 0.05），表明母亲暴露于 PM2.5 与肝癌呈正相关。
结论
我们的荟萃分析表明，PM2.5 暴露与 HCC 患者显著相关。然而，需要更多研究来调查不同空气污染物对 HCC 发病率的综合影响，以提供更全面的证据来评估 PM2.5 暴露对 HCC 发病率的不同水平影响。
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