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药师药理学基因组学和基因组学素养框架的制定。

Development of the pharmacogenomics and genomics literacy framework for pharmacists.

机构信息

Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, UAE.

Department of Genetics and Genomics, College of Medicine and Health Science, United Arab Emirates University, P.O. Box 17666, Al Ain, Abu Dhabi, UAE.

出版信息

Hum Genomics. 2021 Oct 16;15(1):62. doi: 10.1186/s40246-021-00361-0.

Abstract

BACKGROUND

Pharmacists play a unique role in integrating genomic medicine and pharmacogenomics into the clinical practice and to translate pharmacogenomics from bench to bedside. However, the literature suggests that the knowledge gap in pharmacogenomics is a major challenge; therefore, developing pharmacists' skills and literacy to achieve this anticipated role is highly important. We aim to conceptualize a personalized literacy framework for the adoption of genomic medicine and pharmacogenomics by pharmacists in the United Arab Emirates with possible regional and global relevance.

RESULTS

A qualitative approach using focus groups was used to design and to guide the development of a pharmacogenomics literacy framework. The Health Literacy Skills framework was used as a guide to conceptualize the pharmacogenomics literacy for pharmacists. The framework included six major components with specific suggested factors to improve pharmacists' pharmacogenomics literacy. Major components include individual inputs, demand, skills, knowledge, attitude and sociocultural factors.

CONCLUSION

This framework confirms a holistic bottom-up approach toward the implementation of pharmacogenomics. Personalized medicine entails personalized efforts and frameworks. Similar framework can be created for other healthcare providers, patients and stakeholders.

摘要

背景

药剂师在将基因组医学和药物基因组学整合到临床实践中以及将药物基因组学从实验室转化到临床方面发挥着独特的作用。然而,文献表明,药物基因组学方面的知识差距是一个主要挑战;因此,培养药剂师的技能和素养以实现这一预期角色非常重要。我们旨在为阿联酋药剂师采用基因组医学和药物基因组学的目标概念化一个个性化的素养框架,该框架可能具有区域和全球相关性。

结果

采用焦点小组的定性方法来设计和指导药物基因组学素养框架的开发。健康素养技能框架被用作指导药剂师药物基因组学素养的工具。该框架包括六个主要组成部分,并提出了具体的因素来提高药剂师的药物基因组学素养。主要组成部分包括个人投入、需求、技能、知识、态度和社会文化因素。

结论

该框架证实了实施药物基因组学的整体自下而上的方法。个性化医疗需要个性化的努力和框架。类似的框架可以为其他医疗保健提供者、患者和利益相关者创建。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d1/8520199/467768b2d134/40246_2021_361_Fig1_HTML.jpg

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