Cho Doo-Wan, Han Hyoung-Yun, Yang Mi-Jin, Woo Dong Ho, Han Su-Cheol, Yang Young-Su
Jeonbuk Branch Institute, Korea Institute of Toxicology, Jeongeup, Republic of Korea.
Molecular Toxicology Research Group, Korea Institute of Toxicology, Daejeon, Republic of Korea.
Lab Anim Res. 2021 Oct 16;37(1):29. doi: 10.1186/s42826-021-00106-z.
Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device, the animals are either used for other studies or euthanatized.
Herein, we report the case of a living cynomolgus monkey (Macaca fascicularis) that was used for the entire experimental period, instead of euthanasia, after surgical removal of an implanted telemetry system. Radiography was used to determine the status of the implanted telemetry, following which, a repair surgery was performed for removing the system; clinical signs were used to preserve the life of the cynomolgus monkey. Postoperative clinical signs, food consumption, hematology, and serum biochemistry were examined during the 12-month observational period. No abnormal readings or conditions were observed in the subject after implant removal.
This study may be a useful case report for living cynomolgus monkeys in telemetry implantations used throughout the study period. We suggest minimizing the suffering and improving the welfare of these animals.
遥测技术是一种植入式无线设备,用于测量清醒动物的生物信号,研究结束后通常需要通过手术取出。取出设备后,这些动物要么用于其他研究,要么实施安乐死。
在此,我们报告一例食蟹猴(猕猴)的病例,在手术取出植入的遥测系统后,这只食蟹猴在整个实验期间存活下来,而非实施安乐死。通过放射成像确定植入遥测设备的状态,随后进行修复手术以取出该系统;利用临床体征维持食蟹猴的生命。在12个月的观察期内,对术后临床体征、食物摄入量、血液学指标和血清生化指标进行了检查。取出植入物后,该受试动物未观察到任何异常读数或情况。
本研究对于在整个研究期间使用遥测技术植入的存活食蟹猴来说,可能是一份有用的病例报告。我们建议尽量减少这些动物的痛苦并改善其福利。