School of Public Health, The University of Adelaide, South Australia; Robinson Research Institute, The University of Adelaide, South Australia.
Robinson Research Institute, The University of Adelaide, South Australia; South Australian Health and Medical Research Institute, South Australia.
Fertil Steril. 2022 Jan;117(1):202-212. doi: 10.1016/j.fertnstert.2021.08.030. Epub 2021 Oct 13.
To determine the proportion of pregnancies resulting in birth that were conceived with the use of clomiphene citrate (CC) and the frequency of multiple pregnancy.
Whole-of-population cohort study, constructed through data linkage. Comprehensive Australian Government records of dispensed medications were linked to state Perinatal Registry records for all births of at least 20 weeks' gestation.
The state of South Australia.
PATIENT(S): Women who maintained pregnancy for at least 20 weeks and gave birth between July 2003 and December 2015, a total of 150,713 women with 241,561 pregnancies.
INTERVENTION(S): Not applicable.
MAIN OUTCOME MEASURE(S): Ongoing pregnancy occurring in proximity to CC, defined as dispensing from 90 days before to the end of a conception window derived from newborn date of birth and gestational age.
RESULT(S): Linkage to dispensed prescription records was achieved for 97.9% of women. Women who conceived with CC tended to be older and socioeconomically advantaged and more likely than other women to have a history of miscarriage. Ongoing pregnancies associated with CC comprised 1.6% of the total; 5.7% were multiple births (mostly twins, 94.6%) compared with 1.5% in the remainder (98.5% twins).
CONCLUSION(S): In South Australia, 1.6% of pregnancies (1 in 60) of at least 20 weeks' gestation were conceived proximal to CC dispensing. Of these, 5.7% were multiple pregnancies. This takes the proportion of women who achieved an ongoing pregnancy with medical assistance from 4.4%, based on reports from assisted reproductive technology clinics, to 6% in total.
确定使用枸橼酸氯米酚（CC）受孕并导致分娩的妊娠比例以及多胎妊娠的频率。
通过数据链接构建的全人群队列研究。综合澳大利亚政府的药物配给记录与州围产期登记处的所有至少 20 周妊娠的分娩记录相关联。
南澳大利亚州。
至少维持 20 周妊娠并于 2003 年 7 月至 2015 年 12 月之间分娩的妇女，共有 150713 名妇女，241561 例妊娠。
不适用。
与 CC 接近的妊娠持续，定义为从新生儿出生日期和胎龄得出的受孕窗口期前 90 天到结束时的配药。
97.9%的妇女成功与配药记录相联系。使用 CC 受孕的妇女年龄较大，社会经济地位较高，与其他妇女相比，流产史的可能性更高。与 CC 相关的妊娠持续时间占总数的 1.6%；多胎妊娠（主要是双胞胎，94.6%）为 5.7%，而其余（98.5%为双胞胎）为 1.5%。
在南澳大利亚，至少 20 周妊娠的妊娠中（每 60 例中有 1 例），1.6%是在 CC 配药附近受孕的。其中，5.7%是多胎妊娠。这将通过辅助生殖技术诊所报告的 4.4%的比例将接受医学辅助以实现持续妊娠的女性比例提高到 6%。
