• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大肠杆菌K-12 lexA突变体单克隆中细胞分裂的分析。

Analysis of cell division in single clones of the Escherichia coli K-12 lexA mutant.

作者信息

Howe W E, Mount D W

出版信息

J Bacteriol. 1978 Mar;133(3):1278-81. doi: 10.1128/jb.133.3.1278-1281.1978.

DOI:10.1128/jb.133.3.1278-1281.1978
PMID:346566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC222162/
Abstract

The growth of clones of lexA mutant and lexA+ cells was analyzed. During normal growth lexA mutant clones frequently divided early, producing smaller newborn cells than the lexA+ clones. Some newborn cells in the lexA clones did not elongate or divide at all, a response that was never observed in the lexA+ clones. When starved for thymidine, most of the lexA mutant clones elongated and subsequently divided. The majority of lexA+ clones also elongated but did not divide. The above results suggest that one of the functions of the lexA+ gene is coordination of DNA repair with cell division.

摘要

对lexA突变体和lexA+细胞的克隆生长进行了分析。在正常生长过程中，lexA突变体克隆经常过早分裂，产生的新生细胞比lexA+克隆的新生细胞小。lexA克隆中的一些新生细胞根本不伸长或分裂，这种反应在lexA+克隆中从未观察到。当缺乏胸苷时，大多数lexA突变体克隆伸长并随后分裂。大多数lexA+克隆也伸长但不分裂。上述结果表明，lexA+基因的功能之一是协调DNA修复与细胞分裂。

相似文献

1
Analysis of cell division in single clones of the Escherichia coli K-12 lexA mutant.大肠杆菌K-12 lexA突变体单克隆中细胞分裂的分析。
J Bacteriol. 1978 Mar;133(3):1278-81. doi: 10.1128/jb.133.3.1278-1281.1978.
2
Distribution of cell lengths in cultures of a lexA mutant of Escherichia coli K-12.大肠杆菌K-12的lexA突变体培养物中细胞长度的分布。
J Bacteriol. 1979 Apr;138(1):273-4. doi: 10.1128/jb.138.1.273-274.1979.
3
Production of cells without deoxyribonucleic acid during thymidine starvation of lexA- cultures of Escherichia coli K-12.在大肠杆菌K-12的lexA-培养物胸腺嘧啶核苷饥饿期间产生不含脱氧核糖核酸的细胞。
J Bacteriol. 1975 Dec;124(3):1113-21. doi: 10.1128/jb.124.3.1113-1121.1975.
4
Efficient repair of hydrogen peroxide-induced DNA damage by Escherichia coli requires SOS induction of RecA and RuvA proteins.大肠杆菌对过氧化氢诱导的DNA损伤进行有效修复需要SOS诱导RecA和RuvA蛋白。
Mutat Res. 2000 Apr 28;459(3):187-94. doi: 10.1016/s0921-8777(99)00073-7.
5
sfi-independent filamentation in Escherichia coli Is lexA dependent and requires DNA damage for induction.大肠杆菌中不依赖Sfi的丝状化是依赖LexA的，并且诱导需要DNA损伤。
J Bacteriol. 1997 Mar;179(6):1931-9. doi: 10.1128/jb.179.6.1931-1939.1997.
6
Effect of tsl (thermosensitive suppressor of lex) mutation on postreplication repair in Escherichia coli K-12.tsl（lex的热敏抑制子）突变对大肠杆菌K-12中复制后修复的影响。
J Bacteriol. 1978 Sep;135(3):935-42. doi: 10.1128/jb.135.3.935-942.1978.
7
Identification of the lexA gene product of Escherichia coli K-12.
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6147-51. doi: 10.1073/pnas.76.12.6147.
8
Role of Escherichia coli RpoS, LexA and H-NS global regulators in metabolism and survival under aerobic, phosphate-starvation conditions.大肠杆菌RpoS、LexA和H-NS全局调控因子在有氧、磷酸盐饥饿条件下的代谢与存活中的作用
Microbiology (Reading). 1999 Jul;145 ( Pt 7):1547-1562. doi: 10.1099/13500872-145-7-1547.
9
Phosphate starvation and low temperature as well as ultraviolet irradiation transcriptionally induce the Escherichia coli LexA-controlled gene sfiA.磷酸盐饥饿、低温以及紫外线照射会转录诱导大肠杆菌中受LexA调控的基因sfiA。
Mol Microbiol. 1993 May;8(4):697-706. doi: 10.1111/j.1365-2958.1993.tb01613.x.
10
Control of the LexA regulon by pH: evidence for a reversible inactivation of the LexA repressor during the growth cycle of Escherichia coli.pH对LexA调控子的控制：大肠杆菌生长周期中LexA阻遏物可逆失活的证据。
Mol Microbiol. 1994 May;12(4):621-9. doi: 10.1111/j.1365-2958.1994.tb01049.x.

引用本文的文献

1
Coordination between chromosome replication and cell division in Escherichia coli.大肠杆菌中染色体复制与细胞分裂之间的协调
J Bacteriol. 1980 Mar;141(3):1148-56. doi: 10.1128/jb.141.3.1148-1156.1980.
2
Timed action of the gene products required for septum formation in the cell cycle of Bacillus subtilis.枯草芽孢杆菌细胞周期中隔膜形成所需基因产物的定时作用。
J Bacteriol. 1982 Feb;149(2):673-80. doi: 10.1128/jb.149.2.673-680.1982.
3
Role of the sfiA-dependent cell division regulation system in Escherichia coli.sfiA 依赖性细胞分裂调控系统在大肠杆菌中的作用。
J Bacteriol. 1983 Feb;153(2):1072-4. doi: 10.1128/jb.153.2.1072-1074.1983.
4
Coupling between DNA replication and cell division mediated by the FtsA protein in Escherichia coli: a pathway independent of the SOS response, the "TER" pathway.大肠杆菌中由FtsA蛋白介导的DNA复制与细胞分裂之间的偶联：一条独立于SOS反应的途径，即“TER”途径。
J Bacteriol. 1985 Nov;164(2):950-3. doi: 10.1128/jb.164.2.950-953.1985.
5
Distribution of cell lengths in cultures of a lexA mutant of Escherichia coli K-12.大肠杆菌K-12的lexA突变体培养物中细胞长度的分布。
J Bacteriol. 1979 Apr;138(1):273-4. doi: 10.1128/jb.138.1.273-274.1979.

本文引用的文献

1
Pleiotropic effect of the rec A gene of Escherichia coli: uncoupling of cell division from deoxyribonucleic acid replication.大肠杆菌rec A基因的多效性作用：细胞分裂与脱氧核糖核酸复制的解偶联
J Bacteriol. 1971 May;106(2):539-42. doi: 10.1128/jb.106.2.539-542.1971.
2
Suppression of lex mutations affecting deoxyribonucleic acid repair in Escherichia coli K-12 by closely linked thermosensitive mutations.通过紧密连锁的温度敏感突变抑制影响大肠杆菌K-12中脱氧核糖核酸修复的lex突变。
J Bacteriol. 1973 Nov;116(2):950-6. doi: 10.1128/jb.116.2.950-956.1973.
3
Dominant mutations (lex) in Escherichia coli K-12 which affect radiation sensitivity and frequency of ultraviolet lght-induced mutations.大肠杆菌K-12中影响辐射敏感性和紫外线诱导突变频率的显性突变（lex）
J Bacteriol. 1972 Nov;112(2):886-93. doi: 10.1128/jb.112.2.886-893.1972.
4
Prophage induction and cell division in E. coli. III. Mutations sfiA and sfiB restore division in tif and lon strains and permit the expression of mutator properties of tif.大肠杆菌中的原噬菌体诱导与细胞分裂。III. 突变体sfiA和sfiB恢复了tif和lon菌株中的细胞分裂，并使tif的诱变特性得以表达。
Mol Gen Genet. 1975 Oct 22;140(4):309-332.
5
Production of cells without deoxyribonucleic acid during thymidine starvation of lexA- cultures of Escherichia coli K-12.在大肠杆菌K-12的lexA-培养物胸腺嘧啶核苷饥饿期间产生不含脱氧核糖核酸的细胞。
J Bacteriol. 1975 Dec;124(3):1113-21. doi: 10.1128/jb.124.3.1113-1121.1975.
6
DNA content, synthesis and integrity in dividing and non-dividing cells of rec- strains of Escherichia coli K12.大肠杆菌K12 rec-菌株中分裂和非分裂细胞的DNA含量、合成及完整性
J Mol Biol. 1975 Jan 5;91(1):53-66. doi: 10.1016/0022-2836(75)90371-x.
7
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.大肠杆菌中的紫外线诱变与诱导性DNA修复
Bacteriol Rev. 1976 Dec;40(4):869-907. doi: 10.1128/br.40.4.869-907.1976.
8
The induction of protein X in DNA repair and cell division mutants of Escherichia coli.蛋白质X在大肠杆菌DNA修复和细胞分裂突变体中的诱导。
J Mol Biol. 1976 Jul 5;104(3):567-87. doi: 10.1016/0022-2836(76)90121-2.
9
Recalibrated linkage map of Escherichia coli K-12.大肠杆菌K-12的重新校准连锁图谱。
Bacteriol Rev. 1976 Mar;40(1):116-67. doi: 10.1128/br.40.1.116-167.1976.