Olah M E, Rahwan R G
Gen Pharmacol. 1986;17(5):549-52. doi: 10.1016/0306-3623(86)90091-1.
Calcium channel blockers have been advocated as potential therapeutic agents in the management of premature labor. In the present study, the class of intracellular calcium antagonistic methylenedioxyindenes (MDIs) was investigated for potential antiabortifacient activity in mice. Pretreatment of pregnant mice from day 15 of gestation with the MDIs did not afford protection against the abortifacient effect of prostaglandin F2alpha administered from day 17 of gestation. The MDIs demonstrated embryotoxic and fetotoxic activity as shown by a significant increase in the incidence of resorptions and stillbirths. Similar embryotoxicity was previously reported for the calcium channel blockers. It appears doubtful that any of the calcium antagonists so far examined will be clinically useful in the management of premature labor.
钙通道阻滞剂已被推荐作为治疗早产的潜在药物。在本研究中，研究了细胞内钙拮抗剂亚甲二氧基茚类化合物（MDIs）在小鼠体内的潜在抗流产活性。从妊娠第15天开始用MDIs预处理妊娠小鼠，并不能预防从妊娠第17天开始给予的前列腺素F2α的流产作用。MDIs表现出胚胎毒性和胎儿毒性，表现为吸收和死产发生率显著增加。先前有报道称钙通道阻滞剂也有类似的胚胎毒性。目前看来，迄今为止所研究的任何一种钙拮抗剂在临床上用于治疗早产是否有用仍值得怀疑。
