Department of Orthodontic, Collage of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Niger J Clin Pract. 2021 Oct;24(10):1438-1441. doi: 10.4103/njcp.njcp_493_20.
Orthodontic appliances elicit the secretions of some cytokines, chemokines, and growth factors which further have some significances in the remodeling of periodontium tissues. The significant differential forces applied on the periodontium by different types of orthodontic appliances. The secretion of these factors is indirectly responsible for the proper resorption of bones of the periodontal region through molecular signaling, which further supports to facilitate organized movement of the teeth. Objective: In the present study, we carried out the assessment and comparative analysis of the growth factors and chemokines present in the saliva samples of the human subjects of orthodontic treatment with two different treatment modalities: conventional lingual and labial fixed orthodontic appliances.
Total 40 saliva samples were collected of which 20 subjects were treated with the conventional lingual appliances and 20 subjects with the labial fixed appliances. All the salivary samples were acquired from the subjects after 21 days treatment. Cytometric bead array was performed to assess the growth factors and chemokines in the saliva on the flow cytometer.
No significant differences were seen in the growth factor secretion in the saliva of both types of subjects. The same trend was observed for the chemokine secretion in the saliva except CXCL8, CCL11, CCL2, CCL5, and CXCL9.
The similarity in chemokine and growth factor profile between labial and lingual fixed orthodontic appliances indicates that their molecular mechanisms and overall effect on the periodontium are analogous.
正畸矫治器会引发一些细胞因子、趋化因子和生长因子的分泌，这些因子在牙周组织的重塑中具有重要意义。不同类型的正畸矫治器对牙周组织施加的显著差异力。这些因子的分泌通过分子信号间接负责牙周区域骨骼的适当吸收，从而进一步支持牙齿的有组织运动。目的：在本研究中，我们对接受两种不同正畸治疗方式（传统舌侧和唇侧固定正畸矫治器）的正畸治疗患者的唾液样本中的生长因子和趋化因子进行了评估和比较分析。
共采集了 40 份唾液样本，其中 20 名患者接受传统舌侧矫治器治疗，20 名患者接受唇侧固定矫治器治疗。所有唾液样本均在治疗 21 天后从受试者中获得。通过流式细胞仪上的细胞因子珠阵列分析评估唾液中的生长因子和趋化因子。
两种类型的受试者唾液中的生长因子分泌均无显著差异。趋化因子分泌也呈现出相同的趋势，除 CXCL8、CCL11、CCL2、CCL5 和 CXCL9 外。
唇侧和舌侧固定正畸矫治器的趋化因子和生长因子谱相似，表明它们对牙周组织的分子机制和整体影响是类似的。
