IRCCS Neuromed, Via Atinense 18, Pozzilli, IS, Italy.
Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Cerebellum. 2022 Dec;21(6):1029-1051. doi: 10.1007/s12311-021-01335-7. Epub 2021 Oct 16.
Essential tremor (ET) is one of the most common movement disorders. Over the last 10 years, magnetic resonance imaging (MRI) has shed light on the structural and functional abnormalities possibly involved in ET pathophysiology. In this systematic review, we aimed to identify the cortical and subcortical structures involved and the role that different brain areas play in the pathophysiology of motor and non-motor ET features. We found that structural (grey and white matter) cerebellar damage and connectivity alterations between the cerebellum and various cortical areas play a role in both motor and non-motor symptoms of ET. In particular, many studies found an association between MRI findings and non-motor symptoms.
特发性震颤（ET）是最常见的运动障碍之一。在过去的 10 年中，磁共振成像（MRI）揭示了可能与 ET 病理生理学有关的结构和功能异常。在这项系统评价中，我们旨在确定涉及的皮质和皮质下结构，以及不同脑区在运动和非运动 ET 特征的病理生理学中的作用。我们发现结构（灰质和白质）小脑损伤以及小脑与各种皮质区之间的连接改变与 ET 的运动和非运动症状都有关。特别是，许多研究发现 MRI 发现与非运动症状之间存在关联。
