YKL-40 与哮喘的关联：系统荟萃分析。
Association between YKL-40 and asthma: a systematic meta-analysis.
机构信息
Department of Respiratory Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, 100700, China.
Beijing University of Chinese Medicine, Beijing, 100029, China.
出版信息
Sleep Breath. 2022 Sep;26(3):1011-1022. doi: 10.1007/s11325-021-02495-w. Epub 2021 Oct 16.
PURPOSE
Many studies have shown that chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is associated with asthma. The purpose of this meta-analysis was to evaluate the role of serum YKL-40 in the diagnosis and differential diagnosis of asthma, severity grading, and determination of disease state.
METHODS
The PubMed, Ovid, and Cochrane databases were searched. A total of 17 articles involving 5696 subjects were included in this meta-analysis.
RESULTS
The results showed that the level of YKL-40 was significantly higher in asthmatic patients than in the normal group regardless of age and residential location, and increased with severity and acute exacerbation (p < 0.05). YKL-40 levels were significantly different between chronic obstructive pulmonary disease (COPD) and asthma, and also between asthma-COPD overlap syndrome (ACO) and asthma (p < 0.05).
CONCLUSION
YKL-40 may act as a potential serological marker for the diagnosis of asthma, assessment of severity, indicator of the disease state, and differential diagnosis of COPD, ACO, and asthma.
目的
许多研究表明，几丁质酶 3 样蛋白 1（CHI3L1），也称为 YKL-40，与哮喘有关。本荟萃分析的目的是评估血清 YKL-40 在哮喘的诊断和鉴别诊断、严重程度分级以及确定疾病状态中的作用。
方法
检索 PubMed、Ovid 和 Cochrane 数据库。本荟萃分析共纳入 17 项研究，涉及 5696 名受试者。
结果
结果表明，无论年龄和居住地点如何，哮喘患者的 YKL-40 水平明显高于正常组，且随着严重程度和急性加重而升高（p<0.05）。YKL-40 水平在慢性阻塞性肺疾病（COPD）和哮喘之间，以及在哮喘-COPD 重叠综合征（ACO）和哮喘之间存在显著差异（p<0.05）。
结论
YKL-40 可能是一种潜在的血清学标志物，可用于哮喘的诊断、严重程度评估、疾病状态指标以及 COPD、ACO 和哮喘的鉴别诊断。
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